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Details on Person Thrombin-activated PARs activate Gq

Class:Id	Reaction:114558
_displayName	Thrombin-activated PARs activate Gq
_doRelease	TRUE
_timestamp	2020-12-02 14:23:15
catalystActivity	[CatalystActivity:139932] G protein-coupled receptor activity of Thrombin-activated PARs [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
input	[SimpleEntity:29438] GTP [cytosol] [Complex:397803] Thrombin-activated PARs:Gq (inactive) [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:397801] Protease-activated receptors in hemostasis, thrombosis and vascular biology
modified	[InstanceEdit:139921] de Bono, B, 2004-08-10 09:46:55 [InstanceEdit:139985] de Bono, B, 2004-08-12 05:56:15 [InstanceEdit:141660] de Bono, B, 2004-09-25 21:06:36 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:165150] de Bono, B, 2005-07-29 13:11:44 [InstanceEdit:396924] Jupe, S, 2009-03-10 12:52:41 [InstanceEdit:397804] Jupe, S, 2009-03-13 13:33:22 [InstanceEdit:397888] Jupe, S, 2009-03-13 15:52:20 [InstanceEdit:416360] Jupe, S, 2009-03-26 13:50:28 [InstanceEdit:418587] Jupe, S, 2009-04-24 09:58:11 [InstanceEdit:425511] Jupe, S, 2009-06-04 [InstanceEdit:427708] Jupe, S, 2009-06-23 [InstanceEdit:428742] Jupe, S, 2009-07-08 [InstanceEdit:456937] Jupe, S, 2010-01-22 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9708864] Jassal, Bijay, 2020-12-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Thrombin-activated PARs activate Gq Gq activation by PAR
output	[SimpleEntity:29420] GDP [cytosol] [Complex:397802] Thrombin-activated PAR:Gq (active) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:396996] Thrombin-activated PARs binds G-protein Gq [Homo sapiens] [Reaction:114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361727] R-HSA-114558.4
summation	[Summation:178829] Activated PAR stimulates the G alpha (q) subunit to release ...
(hasEvent)	[Pathway:456926] Thrombin signalling through proteinase activated receptors (PARs) [Homo sapiens]
(precedingEvent)	[Reaction:397835] Thrombin-activated PARs:Gq (active) dissociate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791470] Update Tracker - [Reaction:114558] Thrombin-activated PARs activate Gq - v30:[removeLiteratureReference] [_UpdateTracker:9791596] Update Tracker - [Reaction:114558] Thrombin-activated PARs activate Gq - v28:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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