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Details on Person p115-RhoGEF activation of RHOA

Class:Id	Reaction:114544
_displayName	p115-RhoGEF activation of RHOA
_doRelease	TRUE
_timestamp	2018-07-31 13:17:20
catalystActivity	[CatalystActivity:139831] guanyl-nucleotide exchange factor activity of G13-activated p115-RhoGEF [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
edited	[InstanceEdit:435388] Jupe, S, 2009-09-09 [InstanceEdit:9615256] Orlic-Milacic, Marija, 2018-07-31
input	[Complex:8964174] RHOA:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:8874416] Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain
modified	[InstanceEdit:139825] de Bono, B, 2004-08-09 09:46:05 [InstanceEdit:139921] de Bono, B, 2004-08-10 09:46:55 [InstanceEdit:139985] de Bono, B, 2004-08-12 05:56:15 [InstanceEdit:141660] de Bono, B, 2004-09-25 21:06:36 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:165148] de Bono, B, 2005-07-29 13:11:22 [InstanceEdit:399689] Jupe, S, 2009-03-19 11:24:05 [InstanceEdit:400581] Jupe, S, 2009-03-24 10:15:12 [InstanceEdit:418734] Jupe, S, 2009-04-27 08:54:07 [InstanceEdit:419660] Jupe, S, 2009-05-05 12:53:23 [InstanceEdit:419679] Jupe, S, 2009-05-05 15:54:56 [InstanceEdit:421606] Jupe, S, 2009-05-19 09:30:23 [InstanceEdit:421803] Jupe, S, 2009-05-21 12:29:01 [InstanceEdit:425199] Jassal, Bijay, 2009-06-03 [InstanceEdit:435389] Jupe, S, 2009-09-09 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9615256] Orlic-Milacic, Marija, 2018-07-31 [InstanceEdit:9615258] Orlic-Milacic, Marija, 2018-07-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p115-RhoGEF activation of RHOA
output	[Complex:5665993] RHOA:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) [Homo sapiens] [Reaction:380073] Liganded Gi-activating GPCR acts as a GEF for Gi [Homo sapiens] [Reaction:397891] Thrombin-activated PARs:G12/13 (active) dissociate [Homo sapiens] [Reaction:428918] Dissociation of the TP:G13 complex [Homo sapiens] [Reaction:751019] The Ligand:GPCR:G12/13 complex dissociates [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360794] R-HSA-114544.4
summation	[Summation:178379] ARHEF1 (p115-RhoGEF), recruited to the plasma membrane by bi...
(hasEvent)	[Pathway:416482] G alpha (12/13) signalling events [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779160] Update Tracker - [Reaction:114544] p115-RhoGEF activation of RHOA - v66:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by p115-RhoGEF activation of RHOA (114544)