Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person DAG [plasma membrane]

Class:IdSimpleEntity:114519
_displayNameDAG [plasma membrane]
_timestamp2016-01-27 17:58:06
compartment[Compartment:876] plasma membrane
created[InstanceEdit:114498] de Bono, B, 2004-08-04 09:17:50
modified[InstanceEdit:141085] de Bono, B, 2004-08-31 14:25:33
[InstanceEdit:177797] Schmidt, EE, 2006-04-06 13:35:45
[InstanceEdit:1473486] Jupe, S, 2011-08-04
[InstanceEdit:2023204] D'Eustachio, P, 2011-12-06
[InstanceEdit:2656451] Jupe, S, 2012-11-23
[InstanceEdit:8854535] D'Eustachio, Peter, 2016-01-27
[InstanceEdit:9616752] Shorser, Solomon, 2018-08-13
[InstanceEdit:9619952] Wu, G, 2018-09-19
nameDAG
1,2-Diacylglycerol
1,2-diacyl-sn-glycerol
referenceEntity[ReferenceMolecule:549074] 1,2-diacyl-sn-glycerol [ChEBI:17815]
stableIdentifier[StableIdentifier:371676] R-ALL-114519.4
(hasComponent)[Complex:139828] Activated PKC alpha [plasma membrane] [Homo sapiens]
[Complex:139829] Activated PKC beta [plasma membrane] [Homo sapiens]
[Complex:392841] CalDAG-GEFs:DAG:Ca2+ [plasma membrane] [Homo sapiens]
[Complex:422275] Protein Kinase C, alpha type: DAG [plasma membrane] [Homo sapiens]
[Complex:425860] Protein kinase C isoforms, DAG-sensitive:DAG [plasma membrane] [Homo sapiens]
[Complex:425892] CalDAG-GEF1:DAG [plasma membrane] [Mus musculus]
[Complex:426071] Protein kinase C, novel isoforms:DAG [plasma membrane] [Homo sapiens]
[Complex:426179] DAG-activated TRPC3/6/7 [plasma membrane] [Homo sapiens]
[Complex:426343] Activated PKC gamma [plasma membrane] [Homo sapiens]
[Complex:426356] Activated PKC alpha [plasma membrane] [Rattus norvegicus]
List all 20 refering instances
(input)[Reaction:114553] Activation of conventional Protein Kinase C [Homo sapiens]
[Reaction:392831] Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) [Homo sapiens]
[Reaction:400015] Diacylgycerol activates Protein kinase C, alpha type [Homo sapiens]
[Reaction:425861] Activation of Protein Kinase C novel isoforms [Homo sapiens]
[Reaction:425898] Calcium and Diacylglycerol activate Ras guanyl-releasing protein 2 [Mus musculus]
[Reaction:426032] DAG is metabolized by DAGL to 2-AG [Homo sapiens]
[Reaction:426209] DAG activation of TRPC channels [Homo sapiens]
[Reaction:426240] DAG kinase produces phosphatidic acid from DAG [Homo sapiens]
[Reaction:1168373] PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine [Homo sapiens]
[BlackBoxEvent:1168374] RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated [Homo sapiens]
List all 12 refering instances
(output)[Reaction:114689] PLC gamma 2-mediated PIP2 hydrolysis [Homo sapiens]
[Reaction:167686] Active PLCG1 hydrolyses PIP2 [Homo sapiens]
[Reaction:398193] PLC beta-mediated PIP2 hydrolysis [Homo sapiens]
[Reaction:399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Homo sapiens]
[Reaction:429786] SGMS2 transfers phosphocholine onto ceramide [Homo sapiens]
[Reaction:1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate [Homo sapiens]
[Reaction:1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Homo sapiens]
[Reaction:1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Homo sapiens]
[Reaction:8983503] PLC-beta:G-alpha(q/11):DAG:IP3 dissociates to give DAG and IP3 [Homo sapiens]
[Reaction:9682158] Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol [Mus musculus]
List all 12 refering instances
(regulator)[PositiveRegulation:425851] Positive regulation by 'DAG [plasma membrane]'
[PositiveRegulation:1489502] Positive regulation by 'DAG [plasma membrane]'
(replacementInstances)[_Deleted:8848408] Deletion of instance: 2023883
(requiredInputComponent)[Reaction:198314] DAG stimulates protein kinase C-delta [Homo sapiens]
(updatedInstance)[_UpdateTracker:9889867] Update Tracker - [SimpleEntity:114519] DAG [plasma membrane] - v52:[addName]
[_UpdateTracker:9893515] Update Tracker - [SimpleEntity:114519] DAG [plasma membrane] - v56:[add_removeReferenceEntity]
[Change default viewing format]
No pathways have been reviewed or authored by DAG [plasma membrane] (114519)
Follow Reactome