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Details on Person Sequestration of tBID by BCL-2

Class:IdReaction:114352
_displayNameSequestration of tBID by BCL-2
_doReleaseTRUE
_timestamp2017-11-14 15:50:17
compartment[Compartment:17906] mitochondrial outer membrane
created[InstanceEdit:139911] Hardwick, JM, Tsujimoto, Y, 2004-08-09 19:10:09
goBiologicalProcess[GO_BiologicalProcess:139811] negative regulation of apoptotic process
input[EntityWithAccessionedSequence:114266] MYS-BID(61-195) [mitochondrial outer membrane] [Homo sapiens]
[EntityWithAccessionedSequence:50757] BCL2 [mitochondrial outer membrane] [Homo sapiens]
literatureReference[LiteratureReference:114451] Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed
modified[InstanceEdit:114449] Matthews, L, 2004-07-16 10:00:00
[InstanceEdit:114490] Matthews, L, 2004-07-28 17:00:00
[InstanceEdit:139947] Gopinathrao, G, 2004-08-10 16:19:27
[InstanceEdit:140201] Gopinathrao, G, 2004-08-12 15:53:46
[InstanceEdit:141108] Gopinathrao, G, 2004-08-31 15:39:16
[InstanceEdit:141115] Gopinathrao, G, 2004-08-31 17:54:38
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9029235] Orlic-Milacic, Marija, 2017-11-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSequestration of tBID by BCL-2
output[Complex:114339] tBID:BCL-2 [mitochondrial outer membrane] [Homo sapiens]
precedingEvent
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358492] R-HSA-114352.4
summation[Summation:179176] BCL2 binds tBID and inhibits BID-induced cytochrome C releas...
(hasEvent)[Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members [Homo sapiens]
(precedingEvent)[Reaction:139897] BAD displaces tBID from BCL-2 sequestration [Homo sapiens]
(updatedInstance)[_UpdateTracker:9787838] Update Tracker - [Reaction:114352] Sequestration of tBID by BCL-2 - v44:[modifyText]
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