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Details on Person guanyl-nucleotide exchange factor activity

Class:Id	GO_MolecularFunction:11431
_displayName	guanyl-nucleotide exchange factor activity
_timestamp	2009-11-21 18:33:57
accession	0005085
definition	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
modified	[InstanceEdit:160533] Schmidt, EE, 2005-03-23 05:24:35 [InstanceEdit:162607] Schmidt, EE, 2005-04-01 11:06:09 [InstanceEdit:171322] Schmidt, EE, 2006-02-06 10:50:16 [InstanceEdit:258122] Kanapin, EE, 2008-03-27 12:15:20 [InstanceEdit:357819] Kanapin, EE, 2008-06-18 10:45:39 [InstanceEdit:376438] Kanapin, EE, 2008-09-08 10:23:04 [InstanceEdit:383393] Kanapin, AA, 2008-11-26 13:49:44 [InstanceEdit:396309] Kanapin, EE, 2009-03-09 13:26:57 [InstanceEdit:422569] Kanapin, EE [InstanceEdit:436347] Kanapin, EE [InstanceEdit:447572] Kanapin, EE [InstanceEdit:526073] Kanapin, AA [InstanceEdit:528085] Kanapin, AA [InstanceEdit:615500] Kanapin, AA [InstanceEdit:797782] Kanapin, AA [InstanceEdit:937668] Yung, CK [InstanceEdit:1042299] Yung, CK [InstanceEdit:1220942] Yung, CK [InstanceEdit:1301009] Yung, CK [InstanceEdit:1301023] Yung, CK [InstanceEdit:1552540] Yung, CK [InstanceEdit:1996004] Yung, CK [InstanceEdit:2132408] Weiser, JD [InstanceEdit:2133145] Weiser, JD [InstanceEdit:2266118] Weiser, JD [InstanceEdit:2266147] Weiser, JD [InstanceEdit:2454362] Weiser, JD [InstanceEdit:2455542] Weiser, JD [InstanceEdit:2587907] Weiser, JD [InstanceEdit:3132285] Weiser, JD [InstanceEdit:3445953] Weiser, JD [InstanceEdit:4341211] Weiser, JD [InstanceEdit:5083267] Weiser, JD [InstanceEdit:5263134] Weiser, JD [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17
name	guanyl-nucleotide exchange factor activity
referenceDatabase	[ReferenceDatabase:1] GO
(activity)	[CatalystActivity:109806] guanyl-nucleotide exchange factor activity of GRB2-1:SOS1:p-Y427-SHC1 [cytosol] [CatalystActivity:109816] guanyl-nucleotide exchange factor activity of GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] [CatalystActivity:109824] guanyl-nucleotide exchange factor activity of Crk:SOS:IRS-P [cytosol] [CatalystActivity:112375] guanyl-nucleotide exchange factor activity of Grb2:Sos2:p-Y-Irs1 [cytosol] [CatalystActivity:112376] guanyl-nucleotide exchange factor activity of Grb2:Sos2:p-Y-Shc1 [cytosol] [CatalystActivity:139831] guanyl-nucleotide exchange factor activity of G13-activated p115-RhoGEF [plasma membrane] [CatalystActivity:159593] guanyl-nucleotide exchange factor activity of eEF1B complex [cytosol] [CatalystActivity:163619] guanyl-nucleotide exchange factor activity of GCGR:GCG(53-81) [plasma membrane] [CatalystActivity:165126] guanyl-nucleotide exchange factor activity of GEF:DRheb-GDP complex [plasma membrane] [CatalystActivity:169894] guanyl-nucleotide exchange factor activity of Active TrkA receptor:Phospho-ARMS:Crk:C3G complex [plasma membrane] List all 236 refering instances
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No pathways have been reviewed or authored by guanyl-nucleotide exchange factor activity (11431)