Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Release of SMAC (DIABLO) from mitochondria

Class:Id	Reaction:114307
_displayName	Release of SMAC (DIABLO) from mitochondria
_doRelease	TRUE
_timestamp	2018-11-08 19:50:22
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30
input	[EntityWithAccessionedSequence:64637] DIABLO [mitochondrial intermembrane space] [Homo sapiens]
literatureReference	[LiteratureReference:114466] Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. [LiteratureReference:114473] Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. [LiteratureReference:3148617] Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
modified	[InstanceEdit:114401] Matthews, L, 2004-07-15 14:00:00 [InstanceEdit:114462] Matthews, L, 2004-07-20 14:00:00 [InstanceEdit:114471] Matthews, L, 2004-07-28 03:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:180923] Matthews, L, 2006-06-07 20:08:27 [InstanceEdit:3148624] Orlic-Milacic, M, 2013-02-14 [InstanceEdit:3149420] Orlic-Milacic, M, 2013-02-14 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9627098] Shamovsky, Veronica, 2018-11-01 [InstanceEdit:9628510] Shamovsky, Veronica, 2018-11-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Release of SMAC (DIABLO) from mitochondria
output	[EntityWithAccessionedSequence:114298] DIABLO [cytosol] [Homo sapiens]
precedingEvent	[Reaction:114263] Oligomerization of BAK at the mitochondrial membrane [Homo sapiens] [Reaction:139895] tBID activates BAK protein [Homo sapiens] [Reaction:114275] Oligomerization of BAX at the mitochondrial membrane [Homo sapiens] [Reaction:114264] Translocation of activated BAX to the mitochondria [Homo sapiens] [Reaction:139920] Translocation of tBID to mitochondria [Homo sapiens] [Reaction:141367] Myristoylation of tBID by NMT1 [Homo sapiens] [Reaction:180905] Association of Vpr with ANT1 [Homo sapiens] [Reaction:180855] Translocation of Vpr to the mitochondria [Homo sapiens]
regulatedBy	[PositiveRegulation:9029241] Positive regulation by 'Activated BAX,BAK oligomers [mitochondrial outer membrane]'
releaseDate	2004-10-27
reviewed	[InstanceEdit:9620504] Matthews, Lisa, 2018-09-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360751] R-HSA-114307.5
summation	[Summation:3148622] Permeabilization of the outer mitochondrial membrane by pro-...
(hasEvent)	[Pathway:111457] Release of apoptotic factors from the mitochondria [Homo sapiens]
(precedingEvent)	[Pathway:111463] SMAC (DIABLO) binds to IAPs [Homo sapiens] [Pathway:111469] SMAC, XIAP-regulated apoptotic response [Homo sapiens] [Reaction:114306] SMAC binds XIAP:Caspase-3 [Homo sapiens] [Reaction:114354] SMAC binds XIAP:Caspase-7 [Homo sapiens] [Reaction:114361] SMAC binds XIAP within apoptosome [Homo sapiens] [Reaction:9627106] SMAC (DIABLO) forms dimer [Homo sapiens] [Reaction:9627350] SMAC (DIABLO) binds XIAP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778851] Update Tracker - [Reaction:114307] Release of SMAC (DIABLO) from mitochondria - v67:[addLiteratureReference, modifyText] [_UpdateTracker:9780303] Update Tracker - [Reaction:114307] Release of SMAC (DIABLO) from mitochondria - v63:[addRegulator, modifyText] [_UpdateTracker:9788106] Update Tracker - [Reaction:114307] Release of SMAC (DIABLO) from mitochondria - v44:[add_removeSummation]
[Change default viewing format]

No pathways have been reviewed or authored by Release of SMAC (DIABLO) from mitochondria (114307)