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Details on Person SMAC binds XIAP:Caspase-3

Class:IdReaction:114306
_displayNameSMAC binds XIAP:Caspase-3
_doReleaseTRUE
_timestamp2018-11-08 19:50:34
compartment[Compartment:70101] cytosol
created[InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30
edited[InstanceEdit:9628217] Shamovsky, Veronica, 2018-11-07
inferredFrom
input[Complex:114304] XIAP:Caspase-3 [cytosol] [Homo sapiens]
[Complex:9627054] DIABLO dimer [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:114476] Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain
[LiteratureReference:114477] X-linked IAP is a direct inhibitor of cell-death proteases.
[LiteratureReference:114474] Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.
modified[InstanceEdit:114471] Matthews, L, 2004-07-28 03:00:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9627098] Shamovsky, Veronica, 2018-11-01
[InstanceEdit:9628219] Shamovsky, Veronica, 2018-11-07
[InstanceEdit:9628510] Shamovsky, Veronica, 2018-11-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSMAC binds XIAP:Caspase-3
output[Complex:114305] DIABLO:XIAP:Caspase-3 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2004-10-27
reviewed[InstanceEdit:9627969] Matthews, Lisa, 2018-11-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358591] R-HSA-114306.4
summation[Summation:179177] Binding of a dimeric SMAC (DIABLO) N‑terminal peptide with t...
(hasEvent)[Pathway:111463] SMAC (DIABLO) binds to IAPs [Homo sapiens]
(precedingEvent)[Reaction:114419] Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 [Homo sapiens]
[Reaction:202939] Caspase-mediated cleavage of E-Cadherin [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778777] Update Tracker - [Reaction:114306] SMAC binds XIAP:Caspase-3 - v67:[add_removeInput, modifyText]
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No pathways have been reviewed or authored by SMAC binds XIAP:Caspase-3 (114306)