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Details on Person Cleavage of Procaspase-7 by the apoptosome

Class:IdReaction:114261
_displayNameCleavage of Procaspase-7 by the apoptosome
_doReleaseTRUE
_timestamp2018-11-08 19:49:30
authored[InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30
catalystActivity[CatalystActivity:204205] cysteine-type endopeptidase activity of Apoptosome [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30
input[SimpleEntity:113592] ATP [cytosol]
[Complex:6804324] CASP7(2-303) dimer [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:141216] Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
[LiteratureReference:6804328] Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
[LiteratureReference:6804315] Structural basis for the activation of human procaspase-7
[LiteratureReference:6804314] Human caspase-7 activity and regulation by its N-terminal peptide
[LiteratureReference:6804320] Engineered hybrid dimers: tracking the activation pathway of caspase-7
modified[InstanceEdit:114288] Matthews, L, 2004-07-02 10:00:00
[InstanceEdit:141211] Matthews, L, 0000-00-00 00:00:00
[InstanceEdit:141637] Matthews, L, 2004-09-23 23:00:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:212497] Matthews, L, 2008-02-12 15:41:53
[InstanceEdit:213307] Matthews, L, 2008-02-25 10:30:19
[InstanceEdit:266292] Matthews, L, 2008-05-02 11:31:29
[InstanceEdit:6804322] Shamovsky, Veronica, 2015-10-09
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9029238] Orlic-Milacic, Marija, 2017-11-14
[InstanceEdit:9627057] Shamovsky, Veronica, 2018-11-01
[InstanceEdit:9628510] Shamovsky, Veronica, 2018-11-08
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCleavage of Procaspase-7 by the apoptosome
output[Complex:141643] Caspase-7 [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
regulatedBy[NegativeRegulation:9627052] Negative regulation by 'XIAP [cytosol]'
regulationReference[RegulationReference:9642792] Negative regulation by 'XIAP [cytosol]' Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
releaseDate2004-10-27
reviewed[InstanceEdit:9620504] Matthews, Lisa, 2018-09-25
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361215] R-HSA-114261.7
summation[Summation:212499] Caspases-3 and -7 are directly cleaved downstream of caspase...
(hasEvent)[Pathway:111459] Activation of caspases through apoptosome-mediated cleavage [Homo sapiens]
(precedingEvent)[Reaction:201628] Caspase-mediated cleavage of vimentin at DSVD (85) [Homo sapiens]
[Reaction:201634] Caspase-mediated cleavage of FADK 1 [Homo sapiens]
[Reaction:201639] Caspase-mediated cleavage of GAS2 [Homo sapiens]
[BlackBoxEvent:9029680] Caspase-7 translocates to the nucleus [Homo sapiens]
[Reaction:9627107] XIAP binds CASP7 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778928] Update Tracker - [Reaction:114261] Cleavage of Procaspase-7 by the apoptosome - v67:[addRegulator]
[_UpdateTracker:9783975] Update Tracker - [Reaction:114261] Cleavage of Procaspase-7 by the apoptosome - v55:[addLiteratureReference, add_removeInput]
[_UpdateTracker:9791787] Update Tracker - [Reaction:114261] Cleavage of Procaspase-7 by the apoptosome - v25:[addInput, addOutput]
[_UpdateTracker:9791934] Update Tracker - [Reaction:114261] Cleavage of Procaspase-7 by the apoptosome - v24:[add_removeCatalystActivity, add_removeSummation]
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