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Details on Person CYCS:APAF1 binds procaspase-9
Class:Id Reaction:114256 _displayName CYCS:APAF1 binds procaspase-9 _doRelease TRUE _timestamp 2018-11-08 19:49:15 authored [InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30 compartment [Compartment:70101] cytosol created [InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30 edited [InstanceEdit:9628204] Shamovsky, Veronica, 2018-11-07 input [EntityWithAccessionedSequence:57033] CASP9(1-416) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:57033] CASP9(1-416) [cytosol] [Homo sapiens] [Complex:6804555] APAF1:ATP:CYCS [cytosol] [Homo sapiens] [Complex:6804555] APAF1:ATP:CYCS [cytosol] [Homo sapiens] [Complex:6804555] APAF1:ATP:CYCS [cytosol] [Homo sapiens] [Complex:6804555] APAF1:ATP:CYCS [cytosol] [Homo sapiens] [Complex:6804555] APAF1:ATP:CYCS [cytosol] [Homo sapiens] [Complex:6804555] APAF1:ATP:CYCS [cytosol] [Homo sapiens] [Complex:6804555] APAF1:ATP:CYCS [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:57033] CASP9(1-416) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:57033] CASP9(1-416) [cytosol] [Homo sapiens] literatureReference [LiteratureReference:141214] Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. [LiteratureReference:9627385] A near atomic structure of the active human apoptosome [LiteratureReference:9627431] Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome modified [InstanceEdit:141211] Matthews, L, 0000-00-00 00:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:266292] Matthews, L, 2008-05-02 11:31:29 [InstanceEdit:353730] Matthews, L, 2008-06-13 15:10:36 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9029237] Orlic-Milacic, Marija, 2017-11-14 [InstanceEdit:9627057] Shamovsky, Veronica, 2018-11-01 [InstanceEdit:9627414] Shamovsky, Veronica, 2018-11-02 [InstanceEdit:9628219] Shamovsky, Veronica, 2018-11-07 [InstanceEdit:9628510] Shamovsky, Veronica, 2018-11-08 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name CYCS:APAF1 binds procaspase-9 output [Complex:6804619] APAF1:ATP:CYCS heptamer:CASP9 [cytosol] [Homo sapiens] precedingEvent
regulatedBy [NegativeRegulation:9627429] Negative regulation by 'APIP [cytosol]' [NegativeRegulation:9627426] Negative regulation by 'CARD8 [cytosol]' [NegativeRegulation:9627401] Negative regulation by 'AVEN [cytosol]' regulationReference [RegulationReference:9641416] Negative regulation by 'APIP [cytosol]' Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme [RegulationReference:9641618] Negative regulation by 'CARD8 [cytosol]' TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer [RegulationReference:9642778] Negative regulation by 'AVEN [cytosol]' Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1 releaseDate 2004-10-27 reviewed [InstanceEdit:9620504] Matthews, Lisa, 2018-09-25 reviewStatus [ReviewStatus:9821382] five stars revised [InstanceEdit:9628218] Shamovsky, Veronica, 2018-11-07 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:360374] R-HSA-114256.6 summation [Summation:178624] The protease caspase‑9 (CASP9) is normally present as an ina... (hasEvent) [Pathway:111458] Formation of apoptosome [Homo sapiens] (precedingEvent) [Reaction:6804596] APAF1:CYCS binds APIP [Homo sapiens] [Reaction:9627056] Procaspase 9 forms dimer [Homo sapiens] (updatedInstance) [_UpdateTracker:9778939] Update Tracker - [Reaction:114256] CYCS:APAF1 binds procaspase-9 - v67:[addLiteratureReference, addRegulator, add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9791892] Update Tracker - [Reaction:114256] CYCS:APAF1 binds procaspase-9 - v25:[addInput, modifyText]
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