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Details on Person High-resolution structures of free, catalytically active yea...
| Class:Id | Summation:113804 |
|---|---|
| _displayName | High-resolution structures of free, catalytically active yea... |
| _timestamp | 2005-11-10 13:01:14 |
| created | [InstanceEdit:113792] Gopinathrao, G, 2004-06-22 14:12:50 |
| literatureReference | [LiteratureReference:113805] Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution. [LiteratureReference:113806] Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. |
| modified | [InstanceEdit:167899] Matthews, L, 2005-11-10 13:01:09 |
| text | High-resolution structures of free, catalytically active yeast Pol II and of an elongating form reveal that Pol II elongation complex includes features like: - RNA-DNA hybrid, an unwound template ahead of 3'-OH terminus of growing transcript and an exit groove at the base of the CTD, possibly for dynamic interaction of processing and transcriptional factors. - a cleft or channel created by Rpb1 and Rpb2 subunits to accommodate DNA template, extending to Mg2+ ion located deep in the enzyme core -a 50 kDa "clamp" with open confirmation in free polymerase, allowing entry of DNA strands but closed in the processive elongation phase. The clamp is composed of portions of Rpb1,Rpb2 and Rpb3 , five loops or "switches" that change from unfolded to well-folded structures stabilizing the elongation complex, and a long "bridging helix" that emanates from Rpb1 subunit, crossing near the Mg2+ ion. The bridging helix is thought to "bend" to push on the base pair at the 3'-end of RNA-DNA hybrid like a ratchet, translocating Pol II along the DNA (Cramer et al.,2001; Gnatt et al.,2001).In addition to its dynamic biochemical potential, Pol II possess a repertoire of functions to serve as a critical platform of recruiting and coordinating the actions of a host of additional enzyme and proteins involved in various pathways. |
| (summation) | [Reaction:112385] Addition of nucleotides leads to transcript elongation [Homo sapiens] |
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No pathways have been reviewed or authored by High-resolution structures of free, catalytically active yea... (113804)
