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Details on Person Endonucleolytic cleavage separates the pre-mRNA into an upst...

Class:IdSummation:113773
_displayNameEndonucleolytic cleavage separates the pre-mRNA into an upst...
_timestamp2004-09-20 13:52:52
created[InstanceEdit:72178] Wahle, E, 2003-06-05 08:30:31
literatureReference[LiteratureReference:72190] 3'-End processing of pre-mRNA in eukaryotes.
modified[InstanceEdit:141448] Matthews, L, 2004-09-20 15:43:00
textEndonucleolytic cleavage separates the pre-mRNA into an upstream fragment destined to become the mature mRNA and a downstream fragment that is rapidly degraded. Polyadenylation and cleavage occur concurrently, with complexes co-assembling, cleavage depends on two signals in the RNA, a highly conserved hexanucleotide, AAUAAA, 10 to 30 nucleotides upstream of the cleavage site, and a poorly conserved GU- or U-rich downstream element. Additional sequences, often upstream of AAUAAA, can enhance the efficiency of the reaction. Cleavage occurs most often after a CA dinucleotide. A single gene can have more than one 3' processing site.

Cleavage is preceded by the assembly of a large processing complex, the composition of which is poorly defined. ATP, but not its hydrolysis, is required for assembly. Cleavage depends on a number of protein factor. CPSF, a heterotetramer, binds specifically to the AAUAAA sequence. The heterotrimer CstF binds the GU- or U-rich downstream element.

(summation)[Reaction:77590] Recruitment of CstF to the CPSF Bound Pre-mRNA [Homo sapiens]
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