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Details on Person Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
| Class:Id | LiteratureReference:113709 |
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| _displayName | Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation |
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| _timestamp | 2008-02-26 01:03:14 |
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| author | [Person:114190] Connell-Crowley, L
[Person:213379] Harper, JW
[Person:114191] Goodrich, DW |
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| journal | Mol Biol Cell |
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| modified | [InstanceEdit:213369] Matthews, L, 2008-02-26 00:56:34 |
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| pages | 287-301 |
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| pubMedIdentifier | 9190208 |
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| title | Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation |
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| volume | 8 |
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| year | 1997 |
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| (literatureReference) | [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens]
[Reaction:188390] Cyclin E:CDK2-mediated phosphorylation of RB1 [Homo sapiens]
[Pathway:453279] Mitotic G1 phase and G1/S transition [Homo sapiens]
[Reaction:9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes [Homo sapiens]
[RegulationReference:9641568] Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]' Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
[CatalystActivityReference:9643320] cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation |
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