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Details on Person Replication initiation regulation by Rb1/E2F1

Class:Id	Reaction:113643
_displayName	Replication initiation regulation by Rb1/E2F1
_doRelease	TRUE
_timestamp	2016-11-10 00:54:59
authored	[InstanceEdit:113497] Gopinathrao, G, 2004-05-26 17:05:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21
inferredFrom	[Reaction:113649] Replication initiation regulation by E2F1/Rbf1 [Drosophila melanogaster]
input	[Complex:113646] RB1:RNA primer-DNA primer:origin duplex with DNA damage [nucleoplasm] [Homo sapiens] [Complex:68653] E2F1:TFDP1,TFDP2 [nucleoplasm] [Homo sapiens]
modified	[InstanceEdit:113655] Gopinathrao, G, 2004-06-14 19:10:00 [InstanceEdit:113686] Gopinathrao, G, 2004-06-16 19:20:00 [InstanceEdit:113696] Gopinathrao, G, 2004-06-16 19:22:00 [InstanceEdit:113753] Gopinathrao, G, 2004-06-21 13:00:00 [InstanceEdit:114229] 2004-06-28 00:43:28 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:5255454] D'Eustachio, Peter, 2014-02-06 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Replication initiation regulation by Rb1/E2F1
output	[Complex:113648] Aborted replication complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:113503] PP2A mediated localization of RB1 protein in chromatin [Homo sapiens] [Reaction:113504] Detection of damage during initiation of DNA synthesis in S-phase [Homo sapiens] [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens] [Reaction:188390] Cyclin E:CDK2-mediated phosphorylation of RB1 [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359681] R-HSA-113643.3
summation	[Summation:113502] This set of events is inferred from annotated events in Dros...
(hasEvent)	[Pathway:113501] Inhibition of replication initiation of damaged DNA by RB1/E2F1 [Homo sapiens]
(inferredFrom)	[Reaction:1113071] Replication initiation regulation by Rb1/E2F1 [Oryza sativa]
(orthologousEvent)	[Reaction:1113071] Replication initiation regulation by Rb1/E2F1 [Oryza sativa]
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No pathways have been reviewed or authored by Replication initiation regulation by Rb1/E2F1 (113643)