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Details on Person Transcription elongation by RNA polymerase II (RNAPII) is co...
| Class:Id | Summation:113417 |
|---|---|
| _displayName | Transcription elongation by RNA polymerase II (RNAPII) is co... |
| _timestamp | 2011-07-19 17:41:26 |
| created | [InstanceEdit:113400] Gopinathrao, G, 2004-05-06 22:00:00 |
| modified | [InstanceEdit:113713] Gopinathrao, G, 2004-06-20 19:55:54 [InstanceEdit:113792] Gopinathrao, G, 2004-06-22 14:12:50 [InstanceEdit:113847] Gopinathrao, G, 2004-06-23 11:10:00 [InstanceEdit:114227] Joshi-Tope, G, 2004-06-28 00:11:52 [InstanceEdit:169299] Matthews, L, 2005-11-28 23:19:39 [InstanceEdit:1455305] D'Eustachio, P, 2011-07-19 |
| text | Transcription elongation by RNA polymerase II (RNAPII) is controlled by a number of trans-acting transcription elongation factors as well as by cis-acting elements. Transcription elongation is a rate-limiting step for proper mRNA production in which the phosphorylation of Pol II CTD is a crucial biochemical event. The role of CTD phosphorylation in transcription by Pol II is greatly impaired by protein kinase inhibitors such as 5,6-dichloro-1- ribofuranosylbenzimidazole (DRB), which block CTD phosphorylation and induce arrest of elongating Pol II. DRB-sensitive activation Pol II CTD during elongation has enabled the isolation of two sets of factors -Negative Elongation Factors (NELF) and DRB sensitivity inducing factor (DSIF). P-Tefb is a DRB-sensitive, cyclin-dependent CTD kinase composed of Cdk9 that carries out Serine-2 phosphorylation of Pol II CTD during elongation. The mechanism by which DSIF, NELF and P-TEFb act together in Pol II-regulated elongation is yet to be fully understood. Various biochemical evidences point to a model in which DSIF and NELF negatively regulate elongation through interactions with polymerase containing a hypophosphorylated CTD. Subsequent phosphorylation of the Pol II CTD by P-Tefb might promote elongation by inhibiting interactions of DSIF and NELF with the elongation complex. |
| (summation) | [Pathway:113418] Formation of the Early Elongation Complex [Homo sapiens] |
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No pathways have been reviewed or authored by Transcription elongation by RNA polymerase II (RNAPII) is co... (113417)
