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Details on Person DSIF is a heterodimer consisting of hSPT4 (human homolog of ...
| Class:Id | Summation:112416 |
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| _displayName | DSIF is a heterodimer consisting of hSPT4 (human homolog of ... |
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| _timestamp | 2006-01-15 13:13:22 |
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| created | [InstanceEdit:112414] Gopinathrao, G, 2004-05-03 18:16:42 |
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| literatureReference | [LiteratureReference:113797] Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex.
[LiteratureReference:113798] DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. |
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| modified | [InstanceEdit:113792] Gopinathrao, G, 2004-06-22 14:12:50
[InstanceEdit:169297] Matthews, L, 2005-11-28 23:18:51
[InstanceEdit:170768] Matthews, L, 2006-01-15 13:04:15 |
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| text | DSIF is a heterodimer consisting of hSPT4 (human homolog of yeast Spt4- p14) and hSPT5 (human homolog of yeast Spt5-p160). DSIF association with Pol II may be enabled by Spt5 binding to Pol II creating a scaffold for NELF binding (Wada et al.,1998). Spt5 subunit of DSIF can be phosphorylated by P-TEFb. |
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| (summation) | [Reaction:113407] DSIF complex binds to RNA Pol II (hypophosphorylated) [Homo sapiens]
[EntityWithAccessionedSequence:112415] SUPT16H [nucleoplasm] [Homo sapiens] |
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