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Details on Person FCP1 dephosphorylates RNAP II in ternary elongation complexe...
| Class:Id | Summation:112393 |
|---|---|
| _displayName | FCP1 dephosphorylates RNAP II in ternary elongation complexe... |
| _timestamp | 2015-12-12 05:25:25 |
| created | [InstanceEdit:112380] Gopinathrao, G, 2004-04-28 10:54:00 |
| literatureReference | [LiteratureReference:113810] FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation. |
| modified | [InstanceEdit:113400] Gopinathrao, G, 2004-05-06 22:00:00 [InstanceEdit:113713] Gopinathrao, G, 2004-06-20 19:55:54 [InstanceEdit:113792] Gopinathrao, G, 2004-06-22 14:12:50 [InstanceEdit:8849109] May, Bruce, 2015-12-12 |
| text | FCP1 dephosphorylates RNAP II in ternary elongation complexes as well as in solution and is thought to function in the recycling of RNAP II during the transcription cycle. Biochemical experiments suggest that human FCP1 targets CTDs that are phosphorylated at serine 2 (CTD-serine 2) and/or CTD-serine 5. It is also observed to stimulate elongation independent of its catalytic activity. Dephosphorylation of Ser2 - phosphorylated Pol II results in hypophosphorylated form that disengages capping enzymes (CE). |
| (summation) | [Reaction:112383] Hypophosphorylation of RNA Pol II CTD by FCP1P protein [Homo sapiens] |
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No pathways have been reviewed or authored by FCP1 dephosphorylates RNAP II in ternary elongation complexe... (112393)
