Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex

Class:IdReaction:112381
_displayNameHyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
_doReleaseTRUE
_timestamp2023-02-04 15:44:21
authored[InstanceEdit:113400] Gopinathrao, G, 2004-05-06 22:00:00
catalystActivity[CatalystActivity:113431] protein serine/threonine kinase activity of P-TEFb complex [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:77054] Buratowski, S, 2003-10-15 15:18:41
input[Complex:113408] DSIF:NELF:early elongation complex [nucleoplasm] [Homo sapiens]
[Complex:112431] P-TEFb complex [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8932788] AFF4 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8932787] EAF1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8932790] EAF2 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8932789] MLLT3 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:54257] ELL [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8932918] MLLT1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
literatureReference[LiteratureReference:8932796] AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia
modified[InstanceEdit:113400] Gopinathrao, G, 2004-05-06 22:00:00
[InstanceEdit:113713] Gopinathrao, G, 2004-06-20 19:55:54
[InstanceEdit:113792] Gopinathrao, G, 2004-06-22 14:12:50
[InstanceEdit:114227] Joshi-Tope, G, 2004-06-28 00:11:52
[InstanceEdit:159379] Gopinathrao, G, 2005-03-07 18:29:36
[InstanceEdit:159381] Gopinathrao, G, 2005-03-07 18:59:21
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:167175] Gopinathrao, G, 2005-10-11 19:17:30
[InstanceEdit:170259] Matthews, L, 2006-01-03 21:23:50
[InstanceEdit:2671734] D'Eustachio, P, 2012-11-23
[InstanceEdit:8932795] May, Bruce, 2016-07-29
[InstanceEdit:8932799] May, Bruce, 2016-07-29
[InstanceEdit:8932921] May, Bruce, 2016-07-31
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9615483] May, Bruce, 2018-08-07
[InstanceEdit:9827779] May, Bruce, 2023-02-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameHyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
output[Complex:113426] Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] [Homo sapiens]
[Complex:77088] Cap Binding Complex (CBC) [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358743] R-HSA-112381.6
summation[Summation:113428] Cdk-9 is the kinase subunit of P-TEFb that phosphorylates Se...
(hasEvent)[Pathway:112382] Formation of RNA Pol II elongation complex [Homo sapiens]
(inferredFrom)[Reaction:167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex [Homo sapiens]
[Reaction:167191] Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex [Homo sapiens]
(precedingEvent)[Reaction:112379] Recruitment of elongation factors to form elongation complex [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779240] Update Tracker - [Reaction:112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - v66:[addInput, addOutput]
[_UpdateTracker:9782955] Update Tracker - [Reaction:112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - v58:[addInput, addLiteratureReference]
[Change default viewing format]
No pathways have been reviewed or authored by Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (112381)
Follow Reactome