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Details on Person SOS mediated nucleotide exchange of RAS (SHC)

Class:Id	Reaction:112378
_displayName	SOS mediated nucleotide exchange of RAS (SHC)
_doRelease	TRUE
_timestamp	2016-11-10 00:55:40
authored	[InstanceEdit:157820] Charalambous, M, 2005-01-07 11:17:43
catalystActivity	[CatalystActivity:112376] guanyl-nucleotide exchange factor activity of Grb2:Sos2:p-Y-Shc1 [cytosol]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
edited	[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
figure	[Figure:157816] /figures/SOS_ras_SHC.jpg
input	[Complex:112372] p21 Ras:GDP [plasma membrane] [Rattus norvegicus] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:110026] The function of GRB2 in linking the insulin receptor to Ras signaling pathways. [LiteratureReference:187761] The structural basis of the activation of Ras by Sos
modified	[InstanceEdit:112397] Schmidt, EE, 2004-04-29 09:21:20 [InstanceEdit:157832] Schmidt, EE, 2005-01-07 14:20:30 [InstanceEdit:163616] Schmidt, EE, 2005-05-03 09:53:07 [InstanceEdit:5255454] D'Eustachio, Peter, 2014-02-06 [InstanceEdit:5685364] Jupe, Steve, 2015-03-27 [InstanceEdit:5686067] Jupe, Steve, 2015-03-31 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOS mediated nucleotide exchange of RAS (SHC)
output	[Complex:112373] p21 Ras:GTP [plasma membrane] [Rattus norvegicus] [SimpleEntity:29420] GDP [cytosol]
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48895] Rattus norvegicus
stableIdentifier	[StableIdentifier:359155] R-RNO-112378.3
summation	[Summation:157817] SOS promotes the formation of GTP-bound RAS, thus activating...
(inferredFrom)	[Reaction:109807] GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS [Homo sapiens] [Reaction:354152] AlphaIIbbeta3 mediated nucleotide exchange of RAS (SHC) [Homo sapiens] [Reaction:5686071] GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS [Homo sapiens] [Reaction:5686318] GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784778] Update Tracker - [Reaction:112378] SOS mediated nucleotide exchange of RAS (SHC) - v53:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by SOS mediated nucleotide exchange of RAS (SHC) (112378)