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Details on Person thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]

Class:Id	Reaction:112266
_displayName	thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]
_doRelease	TRUE
_timestamp	2025-12-09 23:19:21
catalystActivity	[CatalystActivity:73611] pentosyltransferase activity of TYMP dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643092] transferase activity, transferring pentosyl groups of TYMP dimer [cytosol] Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:112212] D'Eustachio, P, 2004-04-15 11:50:00
crossReference	[DatabaseIdentifier:9976241] RHEA:16039 [DatabaseIdentifier:9976257] RHEA:22826
input	[DefinedSet:500438] Thy, Ura [cytosol] [SimpleEntity:112032] dRibP [cytosol]
literatureReference	[LiteratureReference:500449] Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase [LiteratureReference:500437] Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor [LiteratureReference:74364] Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:500441] D'Eustachio, P, 2010-02-03 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09
name	thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] 2-deoxy-alpha-D-ribose 1-phosphate + thymine => thymidine + phosphate 2-deoxy-alpha-D-ribose 1-phosphate + uracil => 2'-deoxyuridine + phosphate
output	[DefinedSet:500444] Thy-Rib, dU [cytosol] [SimpleEntity:29372] Pi [cytosol]
releaseDate	2004-07-06
reverseReaction	[Reaction:112265] thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] [Homo sapiens] [Reaction:112266] thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360493] R-HSA-112266.5
summation	[Summation:179291] Cytosolic thymidine phosphorylase (TYMP) catalyzes the rever...
(hasEvent)	[Pathway:73614] Pyrimidine salvage [Homo sapiens]
(replacementInstances)	[_Deleted:500462] Deletion of instance: 74377
(reverseReaction)	[Reaction:112265] thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790977] Update Tracker - [Reaction:112266] thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] - v32:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (112266)