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Details on Person CBL [cytosol]

Class:Id	EntityWithAccessionedSequence:112199
_displayName	CBL [cytosol]
_timestamp	2011-11-21 14:45:25
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:109694] de Bono, B, 2004-01-20 06:18:07
endCoordinate	906
modified	[InstanceEdit:113604] Schmidt, EE, 2004-06-09 05:34:08 [InstanceEdit:2006497] Orlic-Milacic, Marija, 2011-11-21
name	CBL CBL E3 ubiquitin protein ligase Signal transduction protein CBL Proto-oncogene c-CBL Casitas B-lineage lymphoma proto-oncogene
referenceEntity	[ReferenceGeneProduct:51488] UniProt:P22681 CBL [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:366188] R-HSA-112199.1
startCoordinate	1
(activeUnit)	[CatalystActivity:183057] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] [CatalystActivity:934571] ubiquitin protein ligase activity of Y55/Y227-pSPRY2:CBL [plasma membrane]
(hasCandidate)	[CandidateSet:8876356] CBL:GRB2,CBL [cytosol] [Homo sapiens]
(hasComponent)	[Complex:182910] CBL:GRB2 [cytosol] [Homo sapiens] [Complex:182914] CBL:SPRY1/2 [cytosol] [Homo sapiens] [Complex:182942] CBL:Beta-Pix [cytosol] [Homo sapiens] [Complex:182956] CBL:Beta-Pix:CDC42:GTP [cytosol] [Homo sapiens] [Complex:182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] [Homo sapiens] [Complex:205182] pAxl:Cbl complex [plasma membrane] [Homo sapiens] [Complex:205200] CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] [Homo sapiens] [Complex:430303] CBL:OSTF1 [cytosol] [Homo sapiens] [Complex:430304] OSTF1:CBL:SRC [cytosol] [Homo sapiens] [Complex:912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Homo sapiens] List all 21 refering instances
(hasMember)	[CandidateSet:8852046] RING-type E3 ubiquitin ligase [cytosol] [Homo sapiens]
(input)	[Reaction:112201] Binding of CBL to APS-P:activated insulin receptor complex [Homo sapiens] [BlackBoxEvent:182988] Sprouty lures CBL away from EGFR [Homo sapiens] [Reaction:183052] CBL binds to GRB2 [Homo sapiens] [Reaction:183055] Binding of CBL to EGFR [Homo sapiens] [Reaction:183094] CDC42:GTP binds CBL:Beta-Pix [Homo sapiens] [Reaction:205228] Interaction of pAxl and Cbl [Homo sapiens] [Reaction:205244] Recruitment of CBL to KIT [Homo sapiens] [Reaction:446362] Clone of ++CBL interacts with SRC and OSTF1 [Homo sapiens] [Reaction:879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated [Homo sapiens] [Reaction:1112690] PTPN11 binds CBL [Homo sapiens] List all 23 refering instances
(output)	[BlackBoxEvent:934585] Ubiquitinated phosphorylated Sprouty2 is degraded by the 26S proteasome [Homo sapiens] [Reaction:1295621] CBL dissociates from ubiquitinated p-SPRY2 [Homo sapiens] [Reaction:4332236] CBL neddylates TGFBR2 [Homo sapiens] [Reaction:9846187] GOCAM CBL neddylates TGFBR2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9871226] Update Tracker - [EntityWithAccessionedSequence:112199] CBL [cytosol] - v39:[modifyEndCoordinate]
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No pathways have been reviewed or authored by CBL [cytosol] (112199)