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Details on Person Oxidative demethylation of 3-meC damaged DNA by ALKBH2

Class:Id	Reaction:112120
_displayName	Oxidative demethylation of 3-meC damaged DNA by ALKBH2
_doRelease	TRUE
_timestamp	2015-02-23 15:45:14
authored	[InstanceEdit:110572] Pegg, A, 2004-02-04 15:50:05
catalystActivity	[CatalystActivity:5656469] dioxygenase activity of ALKBH2:Fe2+:3-meC-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:112119] Joshi-Tope, G, 2004-04-08 22:09:00
edited	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5658055] Orlic-Milacic, Marija, 2014-12-16
input	[SimpleEntity:113671] 2OG [nucleoplasm] [SimpleEntity:113685] O2 [nucleoplasm] [Complex:5657613] ALKBH2:Fe2+:3-meC-dsDNA [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:113684] Reversal of DNA alkylation damage by two human dioxygenases.
modified	[InstanceEdit:113672] Gopinathrao, G, 2004-06-15 18:05:00 [InstanceEdit:113686] Gopinathrao, G, 2004-06-16 19:20:00 [InstanceEdit:113713] Gopinathrao, G, 2004-06-20 19:55:54 [InstanceEdit:159384] Gopinathrao, G, 2005-03-07 19:00:00 [InstanceEdit:159941] Gopinathrao, G, 2005-03-21 18:52:55 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:164579] Gopinathrao, G, 2005-05-27 15:59:40 [InstanceEdit:164595] D'Eustachio, P, 2005-06-02 16:12:01 [InstanceEdit:353207] Saxena, A, 2008-06-12 16:38:55 [InstanceEdit:589906] D'Eustachio, P, 2010-04-12 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:5656471] Orlic-Milacic, Marija, 2014-12-13 [InstanceEdit:5657605] Orlic-Milacic, Marija, 2014-12-15 [InstanceEdit:5657628] Orlic-Milacic, Marija, 2014-12-15 [InstanceEdit:5674552] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5678318] Orlic-Milacic, Marija, 2015-02-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Oxidative demethylation of 3-meC damaged DNA by ALKBH2
output	[SimpleEntity:159939] SUCCA [nucleoplasm] [SimpleEntity:159942] CO2 [nucleoplasm] [GenomeEncodedEntity:5649637] dsDNA [nucleoplasm] [Homo sapiens] [Complex:5656464] ALKBH2:Fe2+ [nucleoplasm] [Homo sapiens] [SimpleEntity:29478] CH2O [nucleoplasm]
precedingEvent	[Reaction:5657665] ALKBH2 binds alkylated dsDNA containing 3-meC [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5672906] Gillespie, Marc E, 2015-02-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5656467] Orlic-Milacic, Marija, 2014-12-13
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104467] R-HSA-112120.2
summation	[Summation:179026] ALKBH2 catalyzes removal of the methyl group from 3-methylcy...
(hasEvent)	[Pathway:112122] ALKBH2 mediated reversal of alkylation damage [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785088] Update Tracker - [Reaction:112120] Oxidative demethylation of 3-meC damaged DNA by ALKBH2 - v52:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
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