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Details on Person UniProt:Q9XTG7 akt-2
| Class:Id | ReferenceGeneProduct:112096 |
|---|---|
| _chainChangeLog | chain:1-528 added on Sat February 7 2015 |
| _displayName | UniProt:Q9XTG7 akt-2 |
| _timestamp | 2026-02-20 21:27:18 |
| chain | chain:1-528 |
| checksum | 9750E8F0AE4F6AE7 |
| comment | FUNCTION Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway (PubMed:10364160, PubMed:11381260, PubMed:11747825, PubMed:15068796, PubMed:18782349, PubMed:22916022, PubMed:9716402). Essential role in regulating developmental arrest at the dauer stage (PubMed:10364160). Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions (PubMed:11381260, PubMed:11747825, PubMed:15068796, PubMed:18358814). Role in immune function and pathogen resistance (PubMed:18782349). Downstream of age-1 and together with akt-1 and sgk-1, promotes cell survival during embryonic development (PubMed:25383666). Plays a role in maintaining the gonadal basement membrane through antagonizing akt-1 activity (PubMed:22916022).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Phosphorylated and activated by pdk-1.SUBUNIT Interacts with pdk-1, sgk-1, akt-1 and daf-16. Part of a complex containing sgk-1, akt-1 and akt-2.ALTERNATIVE PRODUCTS Expressed in neurons, muscle cells of the pharynx, rectal gland cells, and spermatheca.DEVELOPMENTAL STAGE Expressed in late stage embryos and throughout life.DOMAIN The PH domain binds to phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) resulting in its targeting to the plasma membrane.DISRUPTION PHENOTYPE Defective egg-laying and increased resistance to pathogens. Simultaneous knockdown of akt-1 and akt-2 result in dauer formation and a weak extension to life span.SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. |
| created | [InstanceEdit:112058] Matthews, L, 2004-04-06 20:00:00 |
| description | recommendedName: Serine/threonine-protein kinase akt-2 ecNumber: 2.7.11.1 alternativeName: Protein kinase B akt-2 shortName: PKB akt-2 |
| geneName | akt-2 F28H6.1 |
| identifier | Q9XTG7 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Developmental protein Immunity Innate immunity Kinase Magnesium Metal-binding Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | akt-2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | AKT2_CAEEL O77145 |
| sequenceLength | 528 |
| species | [Species:68320] Caenorhabditis elegans |
| (isoformParent) | [ReferenceIsoform:218330] UniProt:Q9XTG7-2 akt-2 [Caenorhabditis elegans] [ReferenceIsoform:415893] UniProt:Q9XTG7-1 akt-2 [Caenorhabditis elegans] |
| (referenceEntity) | [EntityWithAccessionedSequence:112097] AKT-2 [cytosol] [Caenorhabditis elegans] [EntityWithAccessionedSequence:112100] phospho-AKT-2 [cytosol] [Caenorhabditis elegans] |
| (referenceSequence) | [ModifiedResidue:112099] phosphorylated residue at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9XTG7 akt-2 (112096)
