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Details on Person AGE-1 mediated phosphorylation of PIP2 to PIP3

Class:Id	Reaction:112090
_displayName	AGE-1 mediated phosphorylation of PIP2 to PIP3
_doRelease	FALSE
_timestamp	2016-07-15 23:50:38
catalystActivity	[CatalystActivity:112089] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of INS-1:phospho-DAF-2:AAP-1:AGE-1 complex [plasma membrane]
compartment	[Compartment:459] cytoplasm
created	[InstanceEdit:112059] Matthews, L, 2004-04-07 20:00:00
inferredFrom	[Reaction:110453] Phosphorylation of PIP2 to PIP3 by Dp110 [Drosophila melanogaster] [Reaction:109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Homo sapiens]
input	[SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:113592] ATP [cytosol]
modified	[InstanceEdit:112127] Matthews, L, 2004-04-08 04:00:00 [InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:167006] Schmidt, EE, 2005-10-10 15:27:11 [InstanceEdit:2851311] Jupe, S, 2012-12-13 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	AGE-1 mediated phosphorylation of PIP2 to PIP3
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:38117] PIP3 [plasma membrane]
precedingEvent	[Reaction:112091] Association of AGE-1 and AAP-1 with the activated DAF-2 receptor [Caenorhabditis elegans] [Reaction:112066] Autophosphorylation of DAF-2 [Caenorhabditis elegans]
reverseReaction	[Reaction:112095] DAF-18 mediated dephosphorylation of PIP3 to PIP2 [Caenorhabditis elegans] [Reaction:112090] AGE-1 mediated phosphorylation of PIP2 to PIP3 [Caenorhabditis elegans]
species	[Species:68320] Caenorhabditis elegans
stableIdentifier	[StableIdentifier:8924357] R-CEL-112090.1
(hasEvent)	[Pathway:112116] PI3K cascade [Caenorhabditis elegans]
(precedingEvent)	[Reaction:112088] Increased PIP3 recruits AKT-1 to the membrane [Caenorhabditis elegans] [Reaction:112095] DAF-18 mediated dephosphorylation of PIP3 to PIP2 [Caenorhabditis elegans] [Reaction:112102] Increased PIP3 recruits AKT-2 to the membrane [Caenorhabditis elegans] [Pathway:112113] AKT-1/AKT-2 mediated events [Caenorhabditis elegans]
(reverseReaction)	[Reaction:112095] DAF-18 mediated dephosphorylation of PIP3 to PIP2 [Caenorhabditis elegans]
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No pathways have been reviewed or authored by AGE-1 mediated phosphorylation of PIP2 to PIP3 (112090)