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Details on Person UniProt:Q968Y9 daf-2
| Class:Id | ReferenceGeneProduct:112061 |
|---|---|
| _chainChangeLog | signal peptide:1- added on Fri February 6 2015;chain:-966 added on Fri February 6 2015;chain:970-1846 added on Fri February 6 2015 |
| _displayName | UniProt:Q968Y9 daf-2 |
| _timestamp | 2025-02-21 18:37:34 |
| chain | signal peptide:1- chain:-966 chain:970-1846 |
| checksum | 230B28322FF0F126 |
| comment | FUNCTION Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage (PubMed:11743719, PubMed:21334311, PubMed:22916022, PubMed:24332851, PubMed:24385923, PubMed:28853436, PubMed:29500338, PubMed:9252323, PubMed:9790527). Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1 (PubMed:11274053). Required for germline progenitor proliferation during larval development (PubMed:22278922). Plays a role in maintaining gonad integrity in a daf-16/FOXO-dependent manner (PubMed:22916022). Required for the response to environmental stimuli such as light, food, pheromone, and temperature (PubMed:24332851, PubMed:29500338). Negatively regulates resistance to UV and oxidative stress (PubMed:24332851). In a daf-16/FOXO-dependent manner, plays a role in regulating the response to white light (PubMed:29500338). Role in immune function and pathogen resistance (PubMed:18782349). Negatively regulates autophagy (PubMed:22560223). Regulates daf-18/PTEN protein levels (PubMed:23995781). Plays a role in controlling seam cell development during the larval stages (PubMed:21471153).FUNCTION Required for taste avoidance learning in the cell body of ASER gustatory neurons.FUNCTION Required for taste avoidance learning in axons of ASER gustatory neurons.CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)COFACTOR Autophosphorylation activates the kinase activity (By similarity). Interaction with shc-1 may inhibit its activity (PubMed:18832074).SUBUNIT Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain (By similarity). Interacts (via cytoplasmic domain) with shc-1 (PID domain) (PubMed:18832074). Interacts (via kinase domain) with daf-18 (via C-terminus) (PubMed:23995781).SUBUNIT Interacts with casy-1; promoting axonal localization.SUBCELLULAR LOCATION Localizes to the synapse-rich neurite that extends axons. Casy-1 is required for axonal localization.ALTERNATIVE PRODUCTS Accumulation of fat, pigmented intestine, increased lifespan, increased dauer formation and increased resistance to pathogens. Severe loss of function mutants display recessive early embryonic lethality (PubMed:11274053, PubMed:18245374, PubMed:18782349, PubMed:9252323, PubMed:9790527). RNAi-mediated knockdown in germline, hypodermis, intestine or in muscles causes increased lifespan (PubMed:24332851, PubMed:28853436). RNAi-mediated knockdown in a ncl-1 mutant (e1942) background reduces the increased longevity of the daf-2 single mutant, and reduces the increased ribosomal protein synthesis in the ncl-1 single mutant (e1942) (PubMed:28853436). RNAi-mediated knockdown in adults causes an increase in lgg-1 positive autophagic vesicles (PubMed:22560223). RNAi-mediated knockdown results in an increase in the number of muscle arm extensions (PubMed:18436204). RNAi-mediated knockdown together with tatn-1 RNAi extends the lifespan of the single daf-2 RNAi mutant (PubMed:24385923).SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. |
| created | [InstanceEdit:112058] Matthews, L, 2004-04-06 20:00:00 |
| description | recommendedName: fullName evidence="1"Insulin-like receptor shortName evidence="1"IR ecNumber: 2.7.10.1 alternativeName: fullName evidence="30"Abnormal dauer formation protein 2 component recommendedName: fullName evidence="1"Insulin-like receptor subunit alpha /component component recommendedName: fullName evidence="1"Insulin-like receptor subunit beta /component |
| geneName | daf-2 Y55D5A.5 |
| identifier | Q968Y9 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Calcium Carbohydrate metabolism Cell adhesion Cell projection Cleavage on pair of basic residues Developmental protein Disulfide bond Glycoprotein Immunity Innate immunity Kinase Manganese Membrane Metal-binding Nucleotide-binding Phosphoprotein Receptor Reference proteome Repeat Signal Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase |
| modified | [InstanceEdit:398203] Kanapin, AA, 2009-03-18 09:47:27 [InstanceEdit:398262] D'Eustachio, P, 2009-03-18 17:50:41 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:425035] Kanapin, AA [InstanceEdit:436346] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6791590] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | daf-2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | INSR_CAEEL A0A0K3AUY1 B5QS63 O16131 |
| sequenceLength | 1846 |
| species | [Species:68320] Caenorhabditis elegans |
| (isoformParent) | [ReferenceIsoform:9834156] UniProt:Q968Y9-1 daf-2 [Caenorhabditis elegans] [ReferenceIsoform:9834157] UniProt:Q968Y9-3 daf-2 [Caenorhabditis elegans] |
| (referenceEntity) | [EntityWithAccessionedSequence:112062] DAF-2 [plasma membrane] [Caenorhabditis elegans] [EntityWithAccessionedSequence:112065] phospho-DAF-2 [plasma membrane] [Caenorhabditis elegans] |
| (referenceSequence) | [ModifiedResidue:112064] phosphorylated residue at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q968Y9 daf-2 (112061)
