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Details on Person PKC phosphorylates GRK2

Class:Id	Reaction:111970
_displayName	PKC phosphorylates GRK2
_doRelease	TRUE
_timestamp	2016-11-10 00:57:19
authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
catalystActivity	[CatalystActivity:111967] protein serine/threonine kinase activity of active PKC (alpha, gamma, delta) [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:111947] Schmidt, EE, 2004-03-26 09:35:25
input	[EntityWithAccessionedSequence:50270] GRK2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:111971] Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.
modified	[InstanceEdit:111990] Schmidt, EE, 2004-03-31 05:19:10 [InstanceEdit:111998] Schmidt, EE, 2004-03-31 07:59:41 [InstanceEdit:113474] Schmidt, EE, 2004-05-20 07:56:43 [InstanceEdit:387098] Gopinathrao, G, 2008-12-01 01:13:46 [InstanceEdit:732462] Matthews, L, 2010-05-12 [InstanceEdit:843112] Matthews, L, 2010-05-27 [InstanceEdit:1489504] Rothfels, K, 2011-08-15 [InstanceEdit:1566999] Rothfels, K, 2011-09-06 [InstanceEdit:1986605] Rothfels, K, 2011-11-11 [InstanceEdit:2565867] D'Eustachio, P, 2012-11-08 [InstanceEdit:2657083] D'Eustachio, P, 2012-11-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PKC phosphorylates GRK2
output	[EntityWithAccessionedSequence:111969] p-S29-ADRBK1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:112003] Activation of PKC (alpha, gamma, delta) [Homo sapiens] [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol [Homo sapiens]
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387795] R-HSA-111970.3
summation	[Summation:1986604] ADRBK1 (also known as GRK2) is phosphorylated at serine 29 i...
(hasEvent)	[Pathway:111933] Calmodulin induced events [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782555] Update Tracker - [Reaction:111970] PKC phosphorylates GRK2 - v59:[modifyText] [_UpdateTracker:9789006] Update Tracker - [Reaction:111970] PKC phosphorylates GRK2 - v39:[addSummation]
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