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Details on Person Adenylate cyclase produces cAMP

Class:Id	Reaction:111930
_displayName	Adenylate cyclase produces cAMP
_doRelease	TRUE
_timestamp	2025-09-19 09:39:25
authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
catalystActivity	[CatalystActivity:111927] calcium- and calmodulin-responsive adenylate cyclase activity of Adenylate cyclase (Mg2+ cofactor) [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643177] calcium- and calmodulin-responsive adenylate cyclase activity of Adenylate cyclase (Mg2+ cofactor) [plasma membrane] Calmodulin-regulated adenylyl cyclases and neuromodulation.
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:111899] Schmidt, EE, 2004-03-25 09:46:54
crossReference	[DatabaseIdentifier:9946421] RHEA:15390
edited	[InstanceEdit:379927] Jassal, Bijay, 2008-11-06
input	[SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:379022] Calmodulin-binding sites on adenylyl cyclase type VIII [LiteratureReference:379020] The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8
modified	[InstanceEdit:163630] Gopinathrao, G, 2005-05-03 20:44:04 [InstanceEdit:164396] Gopinathrao, G, 2005-05-19 15:02:01 [InstanceEdit:166004] Gopinathrao, G, 2005-08-12 11:14:59 [InstanceEdit:188626] Jassal, Bijay, 2006-10-19 [InstanceEdit:379033] Jassal, Bijay, 2008-10-02 [InstanceEdit:379936] Jassal, Bijay, 2008-11-06 [InstanceEdit:1566993] Rothfels, K, 2011-09-06 [InstanceEdit:2565867] D'Eustachio, P, 2012-11-08 [InstanceEdit:2657083] D'Eustachio, P, 2012-11-23 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9664264] Murillo, Julieth, 2019-10-22 [InstanceEdit:9664534] Murillo, Julieth, 2019-10-25 [InstanceEdit:9667494] Jassal, Bijay, 2019-11-12 [InstanceEdit:9673427] Murillo, Julieth, 2020-01-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9966345] Stephan, Ralf, 2025-09-19
name	Adenylate cyclase produces cAMP
output	[SimpleEntity:30389] cAMP [cytosol] [SimpleEntity:111294] PPi [cytosol]
regulatedBy	[NegativeRegulation:9034476] Negative regulation by 'G-betagamma [plasma membrane]' [PositiveRegulation:9034487] Positive regulation by 'CALM1:4xCa2+ [cytosol]'
releaseDate	2008-12-17
reviewed	[InstanceEdit:379937] Castagnoli, L, 2008-11-06 12:55:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361103] R-HSA-111930.7
summation	[Summation:178450] Adenylate cyclase is responsive to calcium and calmodulin an...
(hasEvent)	[Pathway:163615] PKA activation [Homo sapiens] [Pathway:9664323] FCGR3A-mediated IL10 synthesis [Homo sapiens]
(precedingEvent)	[Reaction:111955] cAMP hydrolysis by Cam-PDE 1 [Homo sapiens] [Reaction:111962] PDE4A,C,D hydrolyse cAMP [Homo sapiens] [Reaction:163628] Autohydrolysis of G-alpha:GTP to G-alpha:GDP [Homo sapiens] [Reaction:8951727] cAMP binds PKA tetramer [Homo sapiens] [Reaction:9644869] p-S54-PDE4B hydrolyses cAMP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779089] Update Tracker - [Reaction:111930] Adenylate cyclase produces cAMP - v66:[add_removeRegulator] [_UpdateTracker:9779885] Update Tracker - [Reaction:111930] Adenylate cyclase produces cAMP - v64:[addRegulator] [_UpdateTracker:9791573] Update Tracker - [Reaction:111930] Adenylate cyclase produces cAMP - v28:[modifyText] [_UpdateTracker:9791678] Update Tracker - [Reaction:111930] Adenylate cyclase produces cAMP - v27:[addLiteratureReference, modifyText]
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