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Details on Person cAMP induces dissociation of inactive PKA tetramers

Class:IdReaction:111925
_displayNamecAMP induces dissociation of inactive PKA tetramers
_doReleaseTRUE
_timestamp2024-01-29 16:24:21
authored[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
catalystActivity[CatalystActivity:9857013] cAMP binding activity of PKA tetramer:4xcAMP [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:111899] Schmidt, EE, 2004-03-25 09:46:54
edited[InstanceEdit:379927] Jassal, Bijay, 2008-11-06
[InstanceEdit:9628239] Orlic-Milacic, Marija, 2018-11-07
input[Complex:8951729] PKA tetramer:4xcAMP [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:379023] Dynamic binding of PKA regulatory subunit RI alpha
modified[InstanceEdit:111947] Schmidt, EE, 2004-03-26 09:35:25
[InstanceEdit:164336] Gopinathrao, G, 2005-05-18 22:14:39
[InstanceEdit:166004] Gopinathrao, G, 2005-08-12 11:14:59
[InstanceEdit:188624] Jassal, Bijay, 2006-10-19
[InstanceEdit:379033] Jassal, Bijay, 2008-10-02
[InstanceEdit:379936] Jassal, Bijay, 2008-11-06
[InstanceEdit:771692] May, B, 2010-05-21
[InstanceEdit:2565867] D'Eustachio, P, 2012-11-08
[InstanceEdit:8951730] Jupe, Steve, 2016-12-09
[InstanceEdit:9628237] Orlic-Milacic, Marija, 2018-11-07
[InstanceEdit:9628240] Orlic-Milacic, Marija, 2018-11-07
[InstanceEdit:9628439] Orlic-Milacic, Marija, 2018-11-08
[InstanceEdit:9664303] Murillo, Julieth, 2019-10-22
[InstanceEdit:9664489] Murillo, Julieth, 2019-10-23
[InstanceEdit:9664534] Murillo, Julieth, 2019-10-25
[InstanceEdit:9673290] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673434] Murillo, Julieth, 2020-01-07
[InstanceEdit:9676962] Murillo, Julieth, 2020-02-24
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9857012] D'Eustachio, Peter, 2023-12-29
[InstanceEdit:9860023] D'Eustachio, Peter, 2024-01-29
[InstanceEdit:9860031] D'Eustachio, Peter, 2024-01-29
namecAMP induces dissociation of inactive PKA tetramers
output[DefinedSet:111920] PKA catalytic subunit [cytosol] [Homo sapiens]
[DefinedSet:111920] PKA catalytic subunit [cytosol] [Homo sapiens]
[Complex:111923] cAMP:PKA regulatory subunit [cytosol] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2008-12-17
reviewed[InstanceEdit:379937] Castagnoli, L, 2008-11-06 12:55:54
[InstanceEdit:9627687] Yi, Feng, 2018-11-02
[InstanceEdit:9628437] Hansen, Kasper B, 2018-11-02
[InstanceEdit:9860022] D'Eustachio, Peter, 2024-01-29
[InstanceEdit:9860030] D'Eustachio, Peter, 2024-01-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359087] R-HSA-111925.7
structureModified[InstanceEdit:9857012] D'Eustachio, Peter, 2023-12-29
summation[Summation:164375] The protein kinase A (PKA) regulatory subunit isoforms diffe...
(hasEvent)[Pathway:163615] PKA activation [Homo sapiens]
[Pathway:164378] PKA activation in glucagon signalling [Homo sapiens]
[Pathway:180024] DARPP-32 events [Homo sapiens]
[Pathway:432040] Vasopressin regulates renal water homeostasis via Aquaporins [Homo sapiens]
[Pathway:442720] CREB1 phosphorylation through the activation of Adenylate Cyclase [Homo sapiens]
[Pathway:9634597] GPER1 signaling [Homo sapiens]
[Pathway:9660821] ADORA2B mediated anti-inflammatory cytokines production [Homo sapiens]
[Pathway:9664323] FCGR3A-mediated IL10 synthesis [Homo sapiens]
[Pathway:9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Homo sapiens]
(precedingEvent)[Reaction:111924] PKA catalytic subunit translocates to the nucleus [Homo sapiens]
[Reaction:163416] hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP [Homo sapiens]
[Reaction:163676] Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA [Homo sapiens]
[Reaction:163773] PKA tetramer:cAMP phosphorylates PF2K-Pase [Homo sapiens]
[Reaction:432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) [Homo sapiens]
[Reaction:9861318] PKA phosphorylates NOS3 (eNOS) on serine-633 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778826] Update Tracker - [Reaction:111925] cAMP induces dissociation of inactive PKA tetramers - v67:[modifyText]
[_UpdateTracker:9781789] Update Tracker - [Reaction:111925] cAMP induces dissociation of inactive PKA tetramers - v60:[add_removeInput]
[_UpdateTracker:9786645] Update Tracker - [Reaction:111925] cAMP induces dissociation of inactive PKA tetramers - v49:[removeRegulator]
[_UpdateTracker:9791663] Update Tracker - [Reaction:111925] cAMP induces dissociation of inactive PKA tetramers - v27:[addLiteratureReference]
[_UpdateTracker:9791733] Update Tracker - [Reaction:111925] cAMP induces dissociation of inactive PKA tetramers - v26:[modifyText]
[_UpdateTracker:9864336] Update Tracker - [Reaction:111925] cAMP induces dissociation of inactive PKA tetramers - v88:[addCatalystActivity]
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