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Details on Person Dimerization of p-S133-CREB1

Class:Id	Reaction:111916
_displayName	Dimerization of p-S133-CREB1
_doRelease	TRUE
_timestamp	2024-01-04 17:10:01
authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:111899] Schmidt, EE, 2004-03-25 09:46:54
edited	[InstanceEdit:379927] Jassal, Bijay, 2008-11-06
inferredFrom	[Reaction:379842] Dimerization of p-S133-Creb1 [Rattus norvegicus]
input	[EntityWithAccessionedSequence:111910] p-S133-CREB1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:111910] p-S133-CREB1 [nucleoplasm] [Homo sapiens]
modified	[InstanceEdit:111947] Schmidt, EE, 2004-03-26 09:35:25 [InstanceEdit:188624] Jassal, Bijay, 2006-10-19 [InstanceEdit:379807] Jassal, B, 2008-11-05 15:52:07 [InstanceEdit:379936] Jassal, Bijay, 2008-11-06 [InstanceEdit:2565867] D'Eustachio, P, 2012-11-08 [InstanceEdit:9615319] Orlic-Milacic, Marija, 2018-08-01 [InstanceEdit:9615327] Orlic-Milacic, Marija, 2018-08-01 [InstanceEdit:9615335] Orlic-Milacic, Marija, 2018-08-01 [InstanceEdit:9615341] Orlic-Milacic, Marija, 2018-08-01 [InstanceEdit:9615396] Orlic-Milacic, Marija, 2018-08-02 [InstanceEdit:9615438] Rothfels, Karen, 2018-08-03 [InstanceEdit:9615502] Orlic-Milacic, Marija, 2018-08-07 [InstanceEdit:9619201] Orlic-Milacic, Marija, 2018-09-14 [InstanceEdit:9623358] Rothfels, Karen, 2018-10-03 [InstanceEdit:9637981] Rothfels, Karen, 2019-02-21 [InstanceEdit:9822862] D'Eustachio, Peter, 2022-12-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9857438] Orlic-Milacic, Marija, 2024-01-04
name	Dimerization of p-S133-CREB1
output	[Complex:111911] p-S133-CREB1 homodimer [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:111912] CaMK4 phosphorylates CREB1 [Homo sapiens] [Reaction:111915] CAMK4 autophosphorylates [Homo sapiens] [Reaction:111919] PKA phosphorylates CREB1 [Homo sapiens] [Reaction:442715] Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP [Homo sapiens] [Reaction:111924] PKA catalytic subunit translocates to the nucleus [Homo sapiens] [Reaction:199298] AKT phosphorylates CREB1 [Homo sapiens] [Reaction:198298] AKT translocates to the nucleus [Homo sapiens] [Reaction:199935] MSK1 activates CREB [Homo sapiens] [Reaction:198756] ERK1/2 phosphorylates MSK1 [Homo sapiens] [Reaction:198669] p38MAPK phosphorylates MSK1 [Homo sapiens] [Reaction:442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) [Homo sapiens] [Reaction:442739] PDPK1 phosphorylates RSKs [Homo sapiens] [Reaction:9612501] SGK phosphorylates CREB1 [Homo sapiens]
releaseDate	2008-12-17
reviewed	[InstanceEdit:379937] Castagnoli, L, 2008-11-06 12:55:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387678] R-HSA-111916.7
summation	[Summation:9615321] Based on studies in rat cells, activation of CREB1 by phosph...
(hasEvent)	[Pathway:111931] PKA-mediated phosphorylation of CREB [Homo sapiens] [Pathway:111932] CaMK IV-mediated phosphorylation of CREB [Homo sapiens] [Pathway:9031628] NGF-stimulated transcription [Homo sapiens] [Pathway:9614083] CREB1-mediated transcription in neuronal development [Homo sapiens] [Pathway:9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling [Homo sapiens]
(precedingEvent)	[Reaction:112286] De-phosphorylation of CREB [Homo sapiens] [Reaction:9615490] p-S133-CREB1 binds MIR132 gene promoter [Homo sapiens] [Reaction:9617217] Phospho-CREB1 binds the promoter of the CEBPB gene [Homo sapiens] [Reaction:9623341] p-S133 CREB1 dimer binds the CCND1 promoter [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779183] Update Tracker - [Reaction:111916] Dimerization of p-S133-CREB1 - v66:[add_removeSummation] [_UpdateTracker:9846806] Update Tracker - [Reaction:111916] Dimerization of p-S119-CREB1 - v84:[modifyText] [_UpdateTracker:9863965] Update Tracker - [Reaction:111916] Dimerization of p-S133-CREB1 - v88:[modifyText]
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