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Details on Person PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine

Class:IdReaction:111883
_displayNamePLA2G4A (cPLA2) hydrolyzes phosphatidylcholine
_doReleaseTRUE
_timestamp2024-08-02 17:21:04
authored[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
catalystActivity[CatalystActivity:111882] A2-type glycerophospholipase activity of Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane]
catalystActivityReference[CatalystActivityReference:9643200] calcium-dependent phospholipase A2 activity of Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane] Functional characterization of mutations in inherited human cPLA? deficiency
compartment[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
[Compartment:17957] endoplasmic reticulum lumen
created[InstanceEdit:111852] Schmidt, EE, 2004-03-24 06:49:11
crossReference[DatabaseIdentifier:9915526] RHEA:40652
edited[InstanceEdit:379927] Jassal, Bijay, 2008-11-06
input[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:9915525] AA-PC [endoplasmic reticulum membrane]
internalReviewed[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
literatureReference[LiteratureReference:2308245] Functional characterization of mutations in inherited human cPLA? deficiency
[LiteratureReference:2308249] Secreted phospholipase A2 revisited
modified[InstanceEdit:111990] Schmidt, EE, 2004-03-31 05:19:10
[InstanceEdit:378481] Jassal, B, 2008-09-18 10:23:12
[InstanceEdit:379005] Jassal, B, 2008-10-02 10:26:24
[InstanceEdit:379936] Jassal, Bijay, 2008-11-06
[InstanceEdit:428983] Jupe, S, 2009-07-13
[InstanceEdit:2308252] D'Eustachio, P, 2012-06-05
[InstanceEdit:2569041] D'Eustachio, P, 2012-11-10
[InstanceEdit:2581441] D'Eustachio, P, 2012-11-13
[InstanceEdit:2629680] D'Eustachio, P, 2012-11-20
[InstanceEdit:8854535] D'Eustachio, Peter, 2016-01-27
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9915527] D'Eustachio, Peter, 2024-07-10
[InstanceEdit:9917361] D'Eustachio, Peter, 2024-08-02
namePLA2G4A (cPLA2) hydrolyzes phosphatidylcholine
1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H+
output[SimpleEntity:29768] AA [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:6814253] LysoPtdCho [endoplasmic reticulum membrane]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2008-12-17
reviewed[InstanceEdit:2569042] Rush, MG, 2012-11-10
[InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:387594] R-HSA-111883.5
structureModified[InstanceEdit:9915527] D'Eustachio, Peter, 2024-07-10
summation[Summation:378471] Once associated with the endoplasmic reticulum membrane, PLA...
(hasEvent)[Pathway:111995] phospho-PLA2 pathway [Homo sapiens]
[Pathway:2142753] Arachidonate metabolism [Homo sapiens]
(precedingEvent)[Reaction:140355] Arachidonate is oxidised to PGG2 by PTGS1 [Homo sapiens]
[Reaction:428990] SLC27A1 transports arachidonate across the ER membrane [Homo sapiens]
[Reaction:2161795] Arachidonate is hydroxylated to 16-HETE by CYP(1) [Homo sapiens]
[Reaction:2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) [Homo sapiens]
[Reaction:2161940] Arachidonate is hydroxylated to 20-HETE by CYP(3) [Homo sapiens]
[Reaction:2309787] Arachidonate is oxidised to PGG2 by PTGS2 [Homo sapiens]
[Reaction:9915992] Arachidonate is hydroxylated to 17-HETE by CYP(1) [Homo sapiens]
[Reaction:9915993] Arachidonate is hydroxylated to 18-HETE by CYP(1) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9783369] Update Tracker - [Reaction:111883] Hydrolysis of phosphatidylcholine - v56:[add_removeInput]
[_UpdateTracker:9788501] Update Tracker - [Reaction:111883] Hydrolysis of phosphatidylcholine - v42:[add_removeLiteratureReference, modifyText]
[_UpdateTracker:9791415] Update Tracker - [Reaction:111883] Hydrolysis of phosphatidylcholine - v30:[add_removeInput, add_removeOutput]
[_UpdateTracker:9919371] Update Tracker - [Reaction:111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine - v90:[add_removeInput, add_removeOutput, modifyText]
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