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Details on Person Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase

Class:Id	Reaction:111881
_displayName	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase
_doRelease	TRUE
_timestamp	2024-08-02 15:49:30
authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
catalystActivity	[CatalystActivity:9915519] A2-type glycerophospholipase activity of p-S505,S727-PLA2G4A [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:111852] Schmidt, EE, 2004-03-24 06:49:11
edited	[InstanceEdit:379927] Jassal, Bijay, 2008-11-06
input	[SimpleEntity:74016] Ca2+ [cytosol] [EntityWithAccessionedSequence:111859] p-S505,S727-PLA2G4A [endoplasmic reticulum membrane] [Homo sapiens] [SimpleEntity:426925] PC [endoplasmic reticulum membrane]
internalReviewed	[InstanceEdit:9915522] D'Eustachio, Peter, 2024-07-10
literatureReference	[LiteratureReference:428975] Intracellular calcium signals regulating cytosolic phospholipase A2 translocation to internal membranes [LiteratureReference:378474] A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP [LiteratureReference:378463] Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells
modified	[InstanceEdit:111947] Schmidt, EE, 2004-03-26 09:35:25 [InstanceEdit:111990] Schmidt, EE, 2004-03-31 05:19:10 [InstanceEdit:378481] Jassal, B, 2008-09-18 10:23:12 [InstanceEdit:379936] Jassal, Bijay, 2008-11-06 [InstanceEdit:428967] Jupe, S, 2009-07-13 [InstanceEdit:428968] Jupe, S, 2009-07-13 [InstanceEdit:428976] Jupe, S, 2009-07-13 [InstanceEdit:934673] Jassal, B, 2010-08-18 [InstanceEdit:934674] Jassal, B, 2010-08-18 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:2327872] D'Eustachio, P, 2012-06-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915520] D'Eustachio, Peter, 2024-07-10 [InstanceEdit:9915523] D'Eustachio, Peter, 2024-07-10 [InstanceEdit:9917349] D'Eustachio, Peter, 2024-08-02
name	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase
output	[Complex:111860] Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:428961] Phosphorylation of cPLA2 by MAPK p38 alpha [Homo sapiens] [BlackBoxEvent:428941] P2Y purinoceptor 1 activates MAP kinase p38 alpha [Homo sapiens] [BlackBoxEvent:432148] Fgr may phosphorylate p38 MAPK [Homo sapiens] [Reaction:435238] PP2A inhibits p38 MAPK [Homo sapiens] [Reaction:432146] SHP-1/2 inhibit p38 MAPK [Reaction:111898] Phosphorylation of cPLA2 by ERK-2 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-12-17
reviewed	[InstanceEdit:379937] Castagnoli, L, 2008-11-06 12:55:54 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387574] R-HSA-111881.3
structureModified	[InstanceEdit:9915520] D'Eustachio, Peter, 2024-07-10
summation	[Summation:378466] The 85kDa cytosolic phospholipase A2 (cPLA2 - PLA2G4A) is in...
(hasEvent)	[Pathway:111995] phospho-PLA2 pathway [Homo sapiens]
(precedingEvent)	[Reaction:111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788411] Update Tracker - [Reaction:111881] Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase - v42:[modifyText] [_UpdateTracker:9791414] Update Tracker - [Reaction:111881] Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase - v30:[addLiteratureReference, add_removeInput] [_UpdateTracker:9919499] Update Tracker - [Reaction:111881] Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase - v90:[modifyText, removeCatalystActivity]
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