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Details on Person RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)

Class:Id	Reaction:111804
_displayName	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)
_doRelease	TRUE
_timestamp	2025-12-04 01:21:42
catalystActivity	[CatalystActivity:111796] ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor of RNR (M1M2B) [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111773] D'Eustachio, P, 2004-04-03 16:52:00
crossReference	[DatabaseIdentifier:9975913] RHEA:23254
input	[SimpleEntity:8866401] NDP(3-) [cytosol] [EntityWithAccessionedSequence:66000] TXN [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:111731] Structure and function of the radical enzyme ribonucleotide reductase [LiteratureReference:111733] Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells [LiteratureReference:111723] Thioredoxin and glutaredoxin systems [LiteratureReference:8866393] Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage [LiteratureReference:8866463] Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells [LiteratureReference:111734] Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase [LiteratureReference:111749] In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase [LiteratureReference:111743] The NMR solution structure of human glutaredoxin in the fully reduced form [LiteratureReference:111775] A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage [LiteratureReference:8866460] Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase [LiteratureReference:499990] A dityrosyl-diiron radical cofactor center is essential for human ribonucleotide reductases
modified	[InstanceEdit:76606] D'Eustachio, P, 2003-10-11 15:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:180352] D'Eustachio, P, 2006-05-18 14:21:13 [InstanceEdit:194431] Schmidt, EE, 2007-03-13 12:34:40 [InstanceEdit:213080] D'Eustachio, P, 2008-02-20 19:55:25 [InstanceEdit:499929] D'Eustachio, P, 2010-01-29 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8866392] D'Eustachio, Peter, 2016-03-31 [InstanceEdit:8866407] D'Eustachio, Peter, 2016-03-31 [InstanceEdit:8866465] D'Eustachio, Peter, 2016-04-01 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975916] D'Eustachio, Peter, 2025-12-04
name	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) a ribonucleoside 5'-diphosphate + (thioredoxin)-dithiol => a 2'-deoxyribonucleoside 5'-diphosphate + (thioredoxin)-disulfide + H2O NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
output	[SimpleEntity:8866399] dNDP(3-) [cytosol] [EntityWithAccessionedSequence:73668] 2xHC-TXN [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[BlackBoxEvent:5632892] TP53 stimulates transcription of RRM2B gene [Homo sapiens] [Reaction:5632887] TP53 binds the RRM2B gene [Homo sapiens] [Reaction:73646] Regeneration of active (reduced) Thioredoxin [Homo sapiens]
regulatedBy	[NegativeRegulation:8866421] Negative regulation by 'dATP [cytosol]' [PositiveRegulation:8866468] Positive regulation by 'ATP [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361327] R-HSA-111804.6
summation	[Summation:213079] Ribonucleotide reductase (RNR (M1M2B)) catalyzes the reducti...
(hasEvent)	[Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens]
(replacementInstances)	[_Deleted:499947] Deletion of instance: 111807 [_Deleted:499948] Deletion of instances: 111816, 111813, 111810, 111803
(updatedInstance)	[_UpdateTracker:9783346] Update Tracker - [Reaction:111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - v57:[addLiteratureReference, addRegulator, add_removeInput, add_removeOutput, modifyText]
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