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Details on Person glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)

Class:Id	Reaction:111746
_displayName	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)
_doRelease	TRUE
_timestamp	2025-12-16 18:01:44
catalystActivity	[CatalystActivity:499937] glutathione disulfide oxidoreductase activity of 2xHC-GLRX [cytosol]
catalystActivityReference	[CatalystActivityReference:9643482] glutathione disulfide oxidoreductase activity of 2xHC-GLRX [cytosol] Purification from placenta, amino acid sequence, structure comparisons and cDNA cloning of human glutaredoxin
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111698] D'Eustachio, P, 2004-03-17 17:27:00
crossReference	[DatabaseIdentifier:9975993] RHEA:21065
input	[EntityWithAccessionedSequence:111740] 2xHC-GLRX [cytosol] [Homo sapiens] [SimpleEntity:29450] GSH [cytosol] [SimpleEntity:29450] GSH [cytosol]
internalReviewed	[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
literatureReference	[LiteratureReference:499936] Purification from placenta, amino acid sequence, structure comparisons and cDNA cloning of human glutaredoxin
modified	[InstanceEdit:143504] D'Eustachio, P, 2004-11-11 20:39:05 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:499929] D'Eustachio, P, 2010-01-29 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975992] D'Eustachio, Peter, 2025-12-04 [InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16 [InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
name	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (protein)-disulfide + 2 glutathione => (protein)-dithiol + glutathione disulfide
output	[EntityWithAccessionedSequence:55729] GLRX [cytosol] [Homo sapiens] [SimpleEntity:111745] GSSG [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361443] R-HSA-111746.5
structureModified	[InstanceEdit:9975992] D'Eustachio, Peter, 2025-12-04
summation	[Summation:499934] Cytosolic glutaredoxin (oxidized) and glutathione (reduced) ...
(hasEvent)	[Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens]
(precedingEvent)	[Reaction:71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ [Homo sapiens] [Reaction:111742] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) [Homo sapiens] [Reaction:8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790837] Update Tracker - [Reaction:111746] glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) - v32:[addCatalystActivity, addLiteratureReference, add_removeSummation]
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No pathways have been reviewed or authored by glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (111746)