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Details on Person IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]

Class:Id	Reaction:111524
_displayName	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
_doRelease	TRUE
_timestamp	2025-12-02 23:58:54
authored	[InstanceEdit:111538] D'Eustachio, P, 2004-02-19 09:47:00
catalystActivity	[CatalystActivity:111492] adenylosuccinate synthase activity of ADSS, ADSSL1 dimers [cytosol]
catalystActivityReference	[CatalystActivityReference:9643738] adenylosuccinate synthase activity of ADSS, ADSSL1 dimers [cytosol] Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111475] D'Eustachio, P, 2004-02-18 17:36:00
crossReference	[DatabaseIdentifier:9975773] RHEA:15754
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[SimpleEntity:29438] GTP [cytosol] [SimpleEntity:29602] IMP [cytosol] [SimpleEntity:29448] L-Asp [cytosol]
literatureReference	[LiteratureReference:111476] Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase [LiteratureReference:500298] Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells
modified	[InstanceEdit:111538] D'Eustachio, P, 2004-02-19 09:47:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:500299] D'Eustachio, P, 2010-02-03 [InstanceEdit:500314] D'Eustachio, P, 2010-02-03 [InstanceEdit:500315] D'Eustachio, P, 2010-02-03 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504067] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9736414] D'Eustachio, Peter, 2021-07-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975767] D'Eustachio, Peter, 2025-12-02
name	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] IMP + L-aspartate + GTP => N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+) inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate
output	[SimpleEntity:29420] GDP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:35141] ADS [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:73797] FAICAR => IMP + H2O [Homo sapiens] [Reaction:73798] AICAR + 10-Formyl-THF => FAICAR + THF [Homo sapiens]
regulatedBy	[NegativeRegulation:111530] Negative regulation by 'ADS [cytosol]' [NegativeRegulation:111531] Negative regulation by 'GMP [cytosol]' [NegativeRegulation:111532] Negative regulation by 'GDP [cytosol]' [NegativeRegulation:111533] Negative regulation by 'F1,6PP [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360186] R-HSA-111524.7
summation	[Summation:111542] Two isoforms of adenylosuccinate synthetase, ADSS and ADSSL1...
(hasEvent)	[Pathway:73817] Purine ribonucleoside monophosphate biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:73828] adenylosuccinate => adenosine 5'-monophosphate + fumarate [Homo sapiens]
(replacementInstances)	[_Deleted:500312] Deletion of instance: 73827
(updatedInstance)	[_UpdateTracker:9775711] Update Tracker - [Reaction:111524] IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] - v78:[addOutput] [_UpdateTracker:9790976] Update Tracker - [Reaction:111524] IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] - v32:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (111524)