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Details on Person Formation of phosphoribosyl pyrophosphate amidotransferase tetramer

Class:Id	Reaction:111285
_displayName	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer
_doRelease	TRUE
_timestamp	2022-02-14 18:35:52
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111282] D'Eustachio, P, 2004-02-11 12:18:00
input	[Complex:73790] PPAT dimer [cytosol] [Homo sapiens] [Complex:73790] PPAT dimer [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:111230] Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties [LiteratureReference:111231] Human glutamine phosphoribosylpyrophosphate amidotransferase. Two molecular forms interconvertible by purine ribonucleotides and phosphoribosylpyrophosphate
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9765093] D'Eustachio, Peter, 2022-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer
negativePrecedingEvent	[NegativePrecedingEvent:9765095] Futile Cycle: Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
output	[Complex:73789] PPAT tetramer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:73797] FAICAR => IMP + H2O [Homo sapiens] [Reaction:73798] AICAR + 10-Formyl-THF => FAICAR + THF [Homo sapiens] [Reaction:73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate [Homo sapiens] [Reaction:73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] [Homo sapiens] [Reaction:73828] adenylosuccinate => adenosine 5'-monophosphate + fumarate [Homo sapiens] [Reaction:111524] IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] [Homo sapiens]
regulatedBy	[PositiveRegulation:111286] Positive regulation by 'adenosine 5'-monophosphate [cytosol]' [PositiveRegulation:111287] Positive regulation by 'GMP [cytosol]' [PositiveRegulation:111288] Positive regulation by 'IMP [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360201] R-HSA-111285.5
summation	[Summation:178791] Cytosolic AMP, GMP, and IMP stimulate the association of pho...
(hasEvent)	[Pathway:73817] Purine ribonucleoside monophosphate biosynthesis [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9765094] Futile Cycle: Formation of phosphoribosyl pyrophosphate amidotransferase tetramer
(updatedInstance)	[_UpdateTracker:9790157] Update Tracker - [Reaction:111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - v35:[modifyText]
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