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Details on Person PTPN11 binds CBL

Class:IdReaction:1112690
_displayNamePTPN11 binds CBL
_doReleaseTRUE
_timestamp2017-11-07 16:13:21
authored[InstanceEdit:1164950] Ray, K, 2010-12-13
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:1112700] Jupe, S, 2010-12-10
edited[InstanceEdit:1112767] Jupe, S, 2010-12-10
input[Complex:1112758] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:112199] CBL [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:1112687] c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130
modified[InstanceEdit:1164953] Jupe, S, 2010-12-13
[InstanceEdit:1214160] Jupe, S, 2011-02-11
[InstanceEdit:8963884] Jupe, Steve, 2017-02-13
[InstanceEdit:9020559] Duenas, Corina, 2017-09-07
[InstanceEdit:9028437] Jupe, Steve, 2017-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePTPN11 binds CBL
SHP2 binds c-Cbl upon IL-6 stimulation
output[Complex:1112744] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2011-03-15
reviewed[InstanceEdit:1214159] Rose-John, S, 2011-02-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1224981] R-HSA-1112690.4
summation[Summation:1112762] SHP2 binds CBL in response to IL-6 stimulation in 293T cells...
(hasEvent)[Pathway:1059683] Interleukin-6 signaling [Homo sapiens]
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No pathways have been reviewed or authored by PTPN11 binds CBL (1112690)