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Details on Person Activated JAKs are believed to be responsible for phosphoryl...

Class:IdSummation:1112600
_displayNameActivated JAKs are believed to be responsible for phosphoryl...
_timestamp2025-12-01 18:25:25
created[InstanceEdit:1112527] Jupe, S, 2010-12-03
literatureReference[LiteratureReference:1164952] Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes
[LiteratureReference:1112534] Tracking STAT nuclear traffic
[LiteratureReference:1112528] Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
[LiteratureReference:1112531] Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation
modified[InstanceEdit:1164953] Jupe, S, 2010-12-13
[InstanceEdit:1168440] Jupe, S, 2010-12-22
[InstanceEdit:8963884] Jupe, Steve, 2017-02-13
[InstanceEdit:9975420] Orlic-Milacic, Marija, 2025-12-01
textActivated JAKs are believed to be responsible for phosphorylating the cytoplasmic region of IL6ST (gp130) (Wang & Fuller 1994, Reich & Liu 2006) creating docking sites for adaptor and downstream signaling molecules, in particular the factors STAT1 and STAT3. Several phosphotyrosine residues of IL6ST are docking sites for STATs (Stahl et al. 1995, Gerhartz et al. 1996). Tyr-759 phosphorylation allows recruitment of the phosphatase SHP2.
(summation)[BlackBoxEvent:1112510] IL6ST is tyrosine phosphorylated [Homo sapiens]
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