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Details on Person Interleukin-6 (IL6) activates the tyrosine phosphorylation o...
| Class:Id | Summation:1112535 |
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| _displayName | Interleukin-6 (IL6) activates the tyrosine phosphorylation o... |
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| _timestamp | 2017-02-13 17:44:42 |
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| created | [InstanceEdit:1112527] Jupe, S, 2010-12-03 |
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| literatureReference | [LiteratureReference:1112553] Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
[LiteratureReference:1112522] Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
[LiteratureReference:1112547] Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation
[LiteratureReference:1112572] Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction
[LiteratureReference:873866] Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions |
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| modified | [InstanceEdit:1112700] Jupe, S, 2010-12-10
[InstanceEdit:8963884] Jupe, Steve, 2017-02-13 |
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| text | Interleukin-6 (IL6) activates the tyrosine phosphorylation of STATs (Akira et al. 1994, Zhong et al. 1994) by receptor-associated JAKs (Hemmann et al. 1996) at a site that is essential for dimerization. For STAT1 this is tyrosine-701, for STAT3 tyrosine-705 (Kaptein et al. 1996, Shuai et al. 1994). Tyrosine phosphorylation leads to homo- or heterodimerization and translocation to the nucleus (Zhong et al. 1994), where the dimers bind to enhancers of IL6- inducible genes e.g. acute phase protein genes, resulting in transcriptional activation. |
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| (summation) | [Reaction:1112602] Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor [Homo sapiens] |
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