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Details on Person POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site

Class:Id	Reaction:111253
_displayName	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site
_doRelease	TRUE
_timestamp	2017-04-28 16:02:08
authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity	[CatalystActivity:5649871] DNA-directed DNA polymerase activity of POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:111239] Matthews, L, 2004-02-09 03:00:00
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input	[SimpleEntity:30555] dNTP [nucleoplasm] [Complex:5649858] POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:111256] Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA.
modified	[InstanceEdit:111316] Matthews, L, 2004-02-11 20:00:00 [InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:5649889] Orlic-Milacic, Marija, 2014-11-21 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674537] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:8866377] D'Eustachio, Peter, 2016-03-31 [InstanceEdit:8986542] Orlic-Milacic, Marija, 2017-04-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site
output	[SimpleEntity:113541] PPi [nucleoplasm] [Complex:5649885] POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5649854] Recruitment of POLB to oxidatively damaged AP site [Homo sapiens] [BlackBoxEvent:5649856] Oxidative damage to the AP site [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5649863] Orlic-Milacic, Marija, 2014-11-21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359219] R-HSA-111253.4
summation	[Summation:179090] DNA polymerase beta (POLB) cannot excise oxidatively damaged...
(hasEvent)	[Pathway:110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway [Homo sapiens]
(precedingEvent)	[Reaction:110364] PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 [Homo sapiens] [Reaction:5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site [Homo sapiens] [Pathway:5651801] PCNA-Dependent Long Patch Base Excision Repair [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783334] Update Tracker - [Reaction:111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site - v57:[add_removeInput] [_UpdateTracker:9785137] Update Tracker - [Reaction:111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site - v52:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
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