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Details on Person DRheb is inhibited by the TSC1/2 complex

Class:Id	Reaction:110491
_displayName	DRheb is inhibited by the TSC1/2 complex
_doRelease	TRUE
_timestamp	2017-08-10 15:44:05
authored	[InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
catalystActivity	[CatalystActivity:110490] GTPase activator activity of DTSC1:DTSC2 complex [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
edited	[InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
goBiologicalProcess	[GO_BiologicalProcess:22611] negative regulation of cell growth
input	[Complex:110415] DRheb-GTP complex [plasma membrane] [Drosophila melanogaster]
literatureReference	[LiteratureReference:110492] Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.
modified	[InstanceEdit:164664] Jassal, B, 2005-06-14 12:46:51 [InstanceEdit:164910] Jassal, B, 2005-07-15 11:22:14 [InstanceEdit:165134] Jassal, B, 2005-07-27 13:55:09 [InstanceEdit:170647] Jassal, B, 2006-01-09 10:49:39 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9015637] D'Eustachio, Peter, 2017-08-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DRheb is inhibited by the TSC1/2 complex
output	[Complex:110416] DRheb-GDP complex [plasma membrane] [Drosophila melanogaster] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:110485] DTSC1 AND DTSC2 form a complex [Drosophila melanogaster] [Reaction:165131] GEF dissociates from DRheb-GTP [Drosophila melanogaster] [Reaction:165129] GDP is exchanged for GTP on DRheb [Drosophila melanogaster]
releaseDate	2006-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8900894] R-DME-110491.2
summation	[Summation:110493] The DTSC1/2 complex antagonizes the amino-acid-TOR signaling...
(hasEvent)	[Pathway:110523] TOR signaling pathway [Drosophila melanogaster]
(precedingEvent)	[Reaction:165127] GEF binds to the inactive DRheb [Drosophila melanogaster]
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No pathways have been reviewed or authored by DRheb is inhibited by the TSC1/2 complex (110491)