Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person DTSC1 AND DTSC2 form a complex

Class:IdReaction:110485
_displayNameDTSC1 AND DTSC2 form a complex
_doReleaseTRUE
_timestamp2017-08-10 15:44:07
authored[InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
compartment[Compartment:70101] cytosol
created[InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
edited[InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
goBiologicalProcess[GO_BiologicalProcess:6196] negative regulation of signal transduction
input[EntityWithAccessionedSequence:110480] TSC1 [cytosol] [Drosophila melanogaster]
[EntityWithAccessionedSequence:110482] GIG [cytosol] [Drosophila melanogaster]
literatureReference[LiteratureReference:110486] The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.
[LiteratureReference:110487] Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.
[LiteratureReference:110488] TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth.
modified[InstanceEdit:164664] Jassal, B, 2005-06-14 12:46:51
[InstanceEdit:164910] Jassal, B, 2005-07-15 11:22:14
[InstanceEdit:165743] de Bono, B, 2005-08-09 13:03:34
[InstanceEdit:170647] Jassal, B, 2006-01-09 10:49:39
[InstanceEdit:5252137] D'Eustachio, Peter, 2014-02-05
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9015637] D'Eustachio, Peter, 2017-08-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDTSC1 AND DTSC2 form a complex
output[Complex:110484] DTSC1:DTSC2 complex [cytosol] [Drosophila melanogaster]
releaseDate2006-01-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:56210] Drosophila melanogaster
stableIdentifier[StableIdentifier:8926607] R-DME-110485.2
summation[Summation:110489] Tuberous sclerosis is a human disease caused by mutated TSC1...
(hasEvent)[Pathway:110523] TOR signaling pathway [Drosophila melanogaster]
(precedingEvent)[Reaction:110491] DRheb is inhibited by the TSC1/2 complex [Drosophila melanogaster]
[Reaction:169828] Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex [Drosophila melanogaster]
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No pathways have been reviewed or authored by DTSC1 AND DTSC2 form a complex (110485)