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Details on Person Increased PIP3 levels recruit DAkt1 to the membrane

Class:Id	Reaction:110463
_displayName	Increased PIP3 levels recruit DAkt1 to the membrane
_doRelease	TRUE
_timestamp	2017-08-10 20:45:37
authored	[InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
edited	[InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
input	[EntityWithAccessionedSequence:110462] AKT1 [cytosol] [Drosophila melanogaster] [SimpleEntity:38117] PIP3 [plasma membrane]
literatureReference	[LiteratureReference:110464] Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.
modified	[InstanceEdit:164664] Jassal, B, 2005-06-14 12:46:51 [InstanceEdit:164800] Jassal, B, 2005-06-23 08:22:11 [InstanceEdit:170647] Jassal, B, 2006-01-09 10:49:39 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9015676] D'Eustachio, Peter, 2017-08-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Increased PIP3 levels recruit DAkt1 to the membrane
output	[Complex:110452] DAkt1:PIP3 complex [plasma membrane] [Drosophila melanogaster]
precedingEvent	[Reaction:110453] Phosphorylation of PIP2 to PIP3 by Dp110 [Drosophila melanogaster] [Reaction:110446] Phospho-Chico: Activated DINR binds p60:Dp110 [Drosophila melanogaster] [Reaction:110459] PIP3 dephosphorylated to PIP2 by DPTEN [Drosophila melanogaster]
releaseDate	2016-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8928979] R-DME-110463.2
summation	[Summation:110465] DAkt (a protein kinase B) is recruited to the plasma membran...
(hasEvent)	[Pathway:110478] Insulin signaling pathway [Drosophila melanogaster]
(inferredFrom)	[Reaction:112088] Increased PIP3 recruits AKT-1 to the membrane [Caenorhabditis elegans] [Reaction:112102] Increased PIP3 recruits AKT-2 to the membrane [Caenorhabditis elegans]
(precedingEvent)	[Reaction:110468] Activation of DAkt1 by DPDK1 [Drosophila melanogaster]
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No pathways have been reviewed or authored by Increased PIP3 levels recruit DAkt1 to the membrane (110463)