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Details on Person Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break

Class:Id	Reaction:110375
_displayName	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break
_doRelease	TRUE
_timestamp	2022-05-12 20:09:17
authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity	[CatalystActivity:5649543] DNA-(apurinic or apyrimidinic site) endonuclease activity of POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input	[Complex:110335] POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:111255] Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.
modified	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:5637651] Orlic-Milacic, Marija, 2014-11-11 [InstanceEdit:5649551] Orlic-Milacic, Marija, 2014-11-20 [InstanceEdit:5651931] Orlic-Milacic, Marija, 2014-11-25 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674545] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674547] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9774035] Matthews, Lisa, 2022-05-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break
output	[SimpleEntity:30977] SUGP [nucleoplasm] [EntityWithAccessionedSequence:50119] APEX1 [nucleoplasm] [Homo sapiens] [Complex:110337] POLB:SSB-gap-dsDNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:110360] Recruitment of POLB to the AP site [Homo sapiens] [Reaction:110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358261] R-HSA-110375.3
summation	[Summation:178713] After incision of the DNA strand 5' to the apurinic/apyrimid...
(hasEvent)	[Pathway:73930] Abasic sugar-phosphate removal via the single-nucleotide replacement pathway [Homo sapiens]
(precedingEvent)	[Reaction:110376] Recruitment of LIG3:XRCC1 complex to the site of repair by POLB [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785195] Update Tracker - [Reaction:110375] Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break - v52:[add_removeCatalystActivity, modifyText] [_UpdateTracker:9785569] Update Tracker - [Reaction:110375] Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break - v51:[addLiteratureReference, modifyText]
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