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Details on Person POLD,POLE-mediated DNA strand displacement synthesis

Class:IdReaction:110368
_displayNamePOLD,POLE-mediated DNA strand displacement synthesis
_doReleaseTRUE
_timestamp2015-02-12 18:21:12
authored[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity[CatalystActivity:5651807] DNA-directed DNA polymerase activity of APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00
edited[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input[Complex:110407] APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [Homo sapiens]
[SimpleEntity:30555] dNTP [nucleoplasm]
[SimpleEntity:30555] dNTP [nucleoplasm]
[SimpleEntity:30555] dNTP [nucleoplasm]
[SimpleEntity:30555] dNTP [nucleoplasm]
[SimpleEntity:30555] dNTP [nucleoplasm]
[SimpleEntity:30555] dNTP [nucleoplasm]
[SimpleEntity:30555] dNTP [nucleoplasm]
[SimpleEntity:30555] dNTP [nucleoplasm]
[SimpleEntity:30555] dNTP [nucleoplasm]
[SimpleEntity:30555] dNTP [nucleoplasm]
literatureReference[LiteratureReference:111247] Replication protein A stimulates proliferating cell nuclear antigen-dependent repair of abasic sites in DNA by human cell extracts.
[LiteratureReference:111254] AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair.
[LiteratureReference:111248] Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).
[LiteratureReference:111256] Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA.
[LiteratureReference:5651883] Mammalian base excision repair by DNA polymerases delta and epsilon
modified[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
[InstanceEdit:111239] Matthews, L, 2004-02-09 03:00:00
[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:2671734] D'Eustachio, P, 2012-11-23
[InstanceEdit:5651806] Orlic-Milacic, Marija, 2014-11-24
[InstanceEdit:5651871] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5651884] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5651937] Orlic-Milacic, Marija, 2014-11-26
[InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11
[InstanceEdit:5674537] Orlic-Milacic, Marija, 2015-02-12
[InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePOLD,POLE-mediated DNA strand displacement synthesis
output[SimpleEntity:113541] PPi [nucleoplasm]
[SimpleEntity:113541] PPi [nucleoplasm]
[SimpleEntity:113541] PPi [nucleoplasm]
[SimpleEntity:113541] PPi [nucleoplasm]
[SimpleEntity:113541] PPi [nucleoplasm]
[SimpleEntity:113541] PPi [nucleoplasm]
[SimpleEntity:113541] PPi [nucleoplasm]
[SimpleEntity:113541] PPi [nucleoplasm]
[SimpleEntity:113541] PPi [nucleoplasm]
[SimpleEntity:113541] PPi [nucleoplasm]
[Complex:5651812] APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2004-03-06
reviewed[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5651802] Orlic-Milacic, Marija, 2014-11-24
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361493] R-HSA-110368.2
summation[Summation:178694] Polymerase delta complex (POLD) or polymerase epsilon comple...
(hasEvent)[Pathway:5651801] PCNA-Dependent Long Patch Base Excision Repair [Homo sapiens]
(precedingEvent)[Reaction:110363] FEN1 bound to PCNA and APEX1 cleaves flap ssDNA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785271] Update Tracker - [Reaction:110368] POLD,POLE-mediated DNA strand displacement synthesis - v52:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by POLD,POLE-mediated DNA strand displacement synthesis (110368)
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