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Details on Person Recruitment of POLB to the AP site

Class:Id	Reaction:110360
_displayName	Recruitment of POLB to the AP site
_doRelease	TRUE
_timestamp	2015-02-12 18:32:41
authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input	[Complex:110334] APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:53845] POLB [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:111255] Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.
modified	[InstanceEdit:111239] Matthews, L, 2004-02-09 03:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:5651931] Orlic-Milacic, Marija, 2014-11-25 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674545] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674547] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of POLB to the AP site
output	[Complex:110335] POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site [Homo sapiens] [Reaction:110349] Displacement of UNG glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110350] Displacement of TDG glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110351] Displacement of SMUG1 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110353] Displacement of MBD4 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110354] Displacement of OGG1 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110355] Displacement of MUTYH glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110356] Displacement of MPG glycosylase by APEX1 at the AP site [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361877] R-HSA-110360.2
summation	[Summation:179133] APEX1 (APE1) bound to the apurinic/apyrimidinic site (AP sit...
(hasEvent)	[Pathway:73930] Abasic sugar-phosphate removal via the single-nucleotide replacement pathway [Homo sapiens]
(precedingEvent)	[Reaction:110375] Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785422] Update Tracker - [Reaction:110360] Recruitment of POLB to the AP site - v52:[modifyText] [_UpdateTracker:9785551] Update Tracker - [Reaction:110360] Recruitment of POLB to the AP site - v51:[modifyText]
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