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Details on Person APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site

Class:Id	Reaction:110359
_displayName	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site
_doRelease	TRUE
_timestamp	2022-09-13 18:03:54
authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity	[CatalystActivity:5649547] DNA endonuclease activity of APEX1:AP-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input	[Complex:110332] APEX1:AP-dsDNA [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:5637648] Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA [LiteratureReference:111255] Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. [LiteratureReference:111250] Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product. [LiteratureReference:111242] Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
modified	[InstanceEdit:111239] Matthews, L, 2004-02-09 03:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671730] D'Eustachio, P, 2012-11-23 [InstanceEdit:5637649] Orlic-Milacic, Marija, 2014-11-11 [InstanceEdit:5649551] Orlic-Milacic, Marija, 2014-11-20 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674537] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:8986534] Orlic-Milacic, Marija, 2017-04-28 [InstanceEdit:9816782] Orlic-Milacic, Marija, 2022-09-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site
output	[Complex:110334] APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:110349] Displacement of UNG glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110215] Cleavage of uracil by UNG glycosylase [Homo sapiens] [Reaction:110217] Cleavage of 5-hydroxyluracil by UNG glycosylase [Homo sapiens] [Reaction:110350] Displacement of TDG glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110218] Cleavage of uracil by TDG glycosylase [Homo sapiens] [Reaction:110219] Cleavage of thymine by TDG glycosylase [Homo sapiens] [Reaction:110234] Cleavage of ethenocytosine by TDG glycosylase [Homo sapiens] [Reaction:110351] Displacement of SMUG1 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110221] Cleavage of uracil by SMUG1 glycosylase [Homo sapiens] [Reaction:110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110224] Cleavage of thymine glycol by NTHL1 glycosylase [Homo sapiens] [Reaction:110226] Cleavage of cytosine glycol by NTHL1 glycosylase [Homo sapiens] [Reaction:110227] Cleavage of dihydrouracil by NTHL1 glycosylase [Homo sapiens] [Reaction:110229] Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase [Homo sapiens] [Reaction:110353] Displacement of MBD4 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110231] Cleavage of uracil by MBD4 glycosylase [Homo sapiens] [Reaction:110232] Cleavage of thymine by MBD4 glycosylase [Homo sapiens] [Reaction:110354] Displacement of OGG1 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110243] Excision of 8-oxoguanine by OGG1 glycosylase [Homo sapiens] [Reaction:110244] Excision of FapyG by OGG1 glycosylase [Homo sapiens] [Reaction:110355] Displacement of MUTYH glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH [Homo sapiens] [Reaction:110356] Displacement of MPG glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110248] Cleavage of 3-methyladenine by MPG glycosylase [Homo sapiens] [Reaction:110250] Cleavage of ethenoadenine by MPG glycosylase [Homo sapiens] [Reaction:110251] Cleavage of hypoxanthine by MPG glycosylase [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358621] R-HSA-110359.4
summation	[Summation:178472] APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site DN...
(hasEvent)	[Pathway:73933] Resolution of Abasic Sites (AP sites) [Homo sapiens]
(precedingEvent)	[Reaction:110360] Recruitment of POLB to the AP site [Homo sapiens] [BlackBoxEvent:5649856] Oxidative damage to the AP site [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785356] Update Tracker - [Reaction:110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - v52:[add_removeCatalystActivity, modifyText] [_UpdateTracker:9785822] Update Tracker - [Reaction:110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - v51:[addLiteratureReference, modifyText]
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