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Details on Person POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template

Class:Id	Reaction:110316
_displayName	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template
_doRelease	TRUE
_timestamp	2015-02-12 19:19:18
authored	[InstanceEdit:110274] Gopinathrao, G, 2004-01-29 18:08:32
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110274] Gopinathrao, G, 2004-01-29 18:08:32
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
input	[EntityWithAccessionedSequence:110287] POLH [nucleoplasm] [Homo sapiens] [Complex:5653905] MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:5653906] Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage [LiteratureReference:111302] Mechanisms of accurate translesion synthesis by human DNA polymerase eta.
modified	[InstanceEdit:111298] Gopinathrao, G, 2004-02-11 18:33:11 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671732] D'Eustachio, P, 2012-11-23 [InstanceEdit:5653910] Orlic-Milacic, Marija, 2014-12-02 [InstanceEdit:5657556] Orlic-Milacic, Marija, 2014-12-13 [InstanceEdit:5663044] Orlic-Milacic, Marija, 2015-01-14 [InstanceEdit:5663081] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5663089] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5663090] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5663092] Orlic-Milacic, Marija, 2015-01-15 [InstanceEdit:5674553] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template Binding of Pol eta to lesioned DNA template
output	[Complex:110288] POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA [Homo sapiens] [Reaction:5652005] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA [Homo sapiens]
regulatedBy	[NegativeRegulation:8986487] Negative regulation by 'RCHY1 [nucleoplasm]'
regulationReference	[RegulationReference:9641276] Negative regulation by 'RCHY1 [nucleoplasm]' Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis
releaseDate	2004-03-06
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5653898] Orlic-Milacic, Marija, 2014-12-02
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359933] R-HSA-110316.4
summation	[Summation:178517] DNA polymerase eta (POLH) belongs to Y family of DNA polymer...
(hasEvent)	[Pathway:110320] Translesion Synthesis by POLH [Homo sapiens]
(precedingEvent)	[Reaction:110317] Insertion of correct bases opposite the lesion by POLH [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780946] Update Tracker - [Reaction:110316] POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template - v61:[addRegulator] [_UpdateTracker:9785011] Update Tracker - [Reaction:110316] POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template - v52:[addLiteratureReference, add_removeInput, modifyText]
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No pathways have been reviewed or authored by POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (110316)