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Details on Person POLZ [nucleoplasm]
Class:Id Complex:110279
_displayName POLZ [nucleoplasm]
_timestamp 2014-11-26 20:36:56
compartment [Compartment:7660] nucleoplasm
created [InstanceEdit:110274] Gopinathrao, G, 2004-01-29 18:08:32
hasComponent
literatureReference [LiteratureReference:5652046] A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 [LiteratureReference:5652042] Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7
modified [InstanceEdit:113515] Schmidt, EE, 2004-06-07 04:20:06 [InstanceEdit:143526] Schmidt, EE, 2004-11-12 06:42:33 [InstanceEdit:5638342] Orlic-Milacic, Marija, 2014-11-13 [InstanceEdit:5652006] Orlic-Milacic, Marija, 2014-11-26 [InstanceEdit:5652048] Orlic-Milacic, Marija, 2014-11-26
name POLZ Pol zeta complex REV3L:MAD2L2
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:363009] R-HSA-110279.1
(activeUnit) [CatalystActivity:110323] DNA-directed DNA polymerase activity of Pol zeta:damaged DNA template complex [nucleoplasm] [CatalystActivity:5652145] DNA-directed DNA polymerase activity of POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] [CatalystActivity:5656154] DNA-directed DNA polymerase activity of POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm]
(hasComponent) [Complex:110280] Pol zeta:damaged DNA template complex [nucleoplasm] [Homo sapiens] [Complex:5652152] POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] [Homo sapiens] [Complex:5655852] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] [Homo sapiens] [Complex:5655912] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] [Homo sapiens] [Complex:5656097] POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] [Homo sapiens] [Complex:5656146] POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] [Homo sapiens]
(input) [Reaction:5652151] REV1 recruits POLZ to (AP:Cyt)-DNA Template [Homo sapiens] [Reaction:5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template [Homo sapiens] [Reaction:5656105] POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA [Homo sapiens]
(output) [Reaction:110311] POLZ extends translesion synthesis [Homo sapiens] [Reaction:110322] Formation of Pol zeta complex [Homo sapiens] [Reaction:5655965] POLK and POLZ cooperate in elongation of mispaired primer termini [Homo sapiens] [Reaction:5656158] POLZ elongates POLI-incorporated dNMP [Homo sapiens]
(updatedInstance) [_UpdateTracker:9889788] Update Tracker - [Complex:110279] POLZ [nucleoplasm] - v52:[addLiteratureReference, addName]
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No pathways have been reviewed or authored by POLZ [nucleoplasm] (110279)