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Details on Person Cleavage of 3-methyladenine by MPG glycosylase
Class:Id Reaction:110248
_displayName Cleavage of 3-methyladenine by MPG glycosylase
_doRelease TRUE
_timestamp 2015-02-12 18:21:04
authored [InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity [CatalystActivity:5649472] DNA N-glycosylase activity of MPG:3meA-dsDNA [nucleoplasm]
compartment [Compartment:7660] nucleoplasm
created [InstanceEdit:110175] Matthews, L, 2004-01-29 08:00:00
edited [InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input [Complex:110202] MPG:3meA-dsDNA [nucleoplasm] [Homo sapiens]
literatureReference [LiteratureReference:5634865] Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16 [LiteratureReference:5634867] Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere [LiteratureReference:5634848] Purification and characterization of human 3-methyladenine-DNA glycosylase [LiteratureReference:5634869] Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision [LiteratureReference:5634882] Release of normal bases from intact DNA by a native DNA repair enzyme
modified [InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00 [InstanceEdit:111239] Matthews, L, 2004-02-09 03:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671733] D'Eustachio, P, 2012-11-23 [InstanceEdit:5634881] Orlic-Milacic, Marija, 2014-11-06 [InstanceEdit:5634887] Orlic-Milacic, Marija, 2014-11-06 [InstanceEdit:5649480] Orlic-Milacic, Marija, 2014-11-20 [InstanceEdit:5658589] Orlic-Milacic, Marija, 2014-12-19 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674537] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name Cleavage of 3-methyladenine by MPG glycosylase
output [SimpleEntity:30947] MADE [nucleoplasm] [Complex:110207] MPG:AP-dsDNA [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate 2004-03-06
reviewed [InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus [ReviewStatus:9821382] five stars
revised [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:358814] R-HSA-110248.2
summation [Summation:178539] MPG, a 3-methyladenine DNA glycosylase, removes the alkylate...
(hasEvent) [Pathway:110331] Cleavage of the damaged purine [Homo sapiens]
(precedingEvent) [Reaction:110356] Displacement of MPG glycosylase by APEX1 at the AP site [Homo sapiens]
(updatedInstance) [_UpdateTracker:9784925] Update Tracker - [Reaction:110248] Cleavage of 3-methyladenine by MPG glycosylase - v52:[add_removeCatalystActivity, removeLiteratureReference] [_UpdateTracker:9785704] Update Tracker - [Reaction:110248] Cleavage of 3-methyladenine by MPG glycosylase - v51:[addLiteratureReference, modifyText]
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