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Details on Person Cleavage of adenine mispaired with 8-oxoguanine by MUTYH

Class:Id	Reaction:110246
_displayName	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH
_doRelease	TRUE
_timestamp	2018-06-29 14:36:36
authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity	[CatalystActivity:5649473] DNA N-glycosylase activity of MUTYH:(8oxoG:Ade)-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110175] Matthews, L, 2004-01-29 08:00:00
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03 [InstanceEdit:9612698] Orlic-Milacic, Marija, 2018-06-29
input	[Complex:110199] MUTYH:(8oxoG:Ade)-dsDNA [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:5635925] Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria [LiteratureReference:5635939] hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs [LiteratureReference:9606843] Adenine excisional repair function of MYH protein on the adenine:8-hydroxyguanine base pair in double-stranded DNA
modified	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00 [InstanceEdit:111239] Matthews, L, 2004-02-09 03:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671733] D'Eustachio, P, 2012-11-23 [InstanceEdit:5635948] Orlic-Milacic, Marija, 2014-11-07 [InstanceEdit:5649480] Orlic-Milacic, Marija, 2014-11-20 [InstanceEdit:5658588] Orlic-Milacic, Marija, 2014-12-19 [InstanceEdit:5659704] Orlic-Milacic, Marija, 2014-12-22 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674537] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9606847] Orlic-Milacic, Marija, 2018-04-25 [InstanceEdit:9612702] Orlic-Milacic, Marija, 2018-06-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cleavage of adenine mispaired with 8-oxoguanine by MUTYH
output	[Complex:110200] MUTYH:AP-dsDNA [nucleoplasm] [Homo sapiens] [SimpleEntity:5635947] Ade [nucleoplasm]
precedingEvent	[Reaction:110237] MUTYH mediated recognition and binding of an adenine opposite to an 8-oxoguanine [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22 [InstanceEdit:9612701] Nakabeppu, Yusaku, 2018-06-28
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359538] R-HSA-110246.4
summation	[Summation:178535] MUTYH (MYH) functions as an adenine DNA glycosylase and remo...
(hasEvent)	[Pathway:110331] Cleavage of the damaged purine [Homo sapiens]
(normalReaction)	[FailedReaction:9605313] Defective MUTYH mutants do not cleave adenine mispaired with 8-oxoguanine [Homo sapiens]
(precedingEvent)	[Reaction:110355] Displacement of MUTYH glycosylase by APEX1 at the AP site [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779288] Update Tracker - [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - v66:[modifyText] [_UpdateTracker:9779306] Update Tracker - [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - v65:[addLiteratureReference, modifyText] [_UpdateTracker:9785170] Update Tracker - [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - v52:[add_removeCatalystActivity, add_removeLiteratureReference] [_UpdateTracker:9785818] Update Tracker - [Reaction:110246] Cleavage of adenine mispaired with 8-oxoguanine by MUTYH - v51:[add_removeOutput, modifyText]
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