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Details on Person Excision of FapyG by OGG1 glycosylase

Class:Id	Reaction:110244
_displayName	Excision of FapyG by OGG1 glycosylase
_doRelease	TRUE
_timestamp	2019-10-21 19:50:52
authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity	[CatalystActivity:5643992] oxidized purine nucleobase lesion DNA N-glycosylase activity of OGG1:FapyG-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110175] Matthews, L, 2004-01-29 08:00:00
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03 [InstanceEdit:9663704] Orlic-Milacic, Marija, 2019-10-10
input	[Complex:110186] OGG1:FapyG-dsDNA [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:5635978] Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes
modified	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00 [InstanceEdit:111239] Matthews, L, 2004-02-09 03:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671733] D'Eustachio, P, 2012-11-23 [InstanceEdit:5636005] Orlic-Milacic, Marija, 2014-11-08 [InstanceEdit:5636008] Orlic-Milacic, Marija, 2014-11-08 [InstanceEdit:5644010] Orlic-Milacic, Marija, 2014-11-19 [InstanceEdit:5651910] Orlic-Milacic, Marija, 2014-11-25 [InstanceEdit:5658608] Orlic-Milacic, Marija, 2014-12-19 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674537] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9663708] Orlic-Milacic, Marija, 2019-10-10 [InstanceEdit:9663887] Orlic-Milacic, Marija, 2019-10-16 [InstanceEdit:9664205] Orlic-Milacic, Marija, 2019-10-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Excision of FapyG by OGG1 glycosylase
output	[Complex:110195] OGG1:AP-dsDNA [nucleoplasm] [Homo sapiens] [SimpleEntity:5636006] FapyG [nucleoplasm]
precedingEvent	[Reaction:110236] OGG1 glycosylase mediated recognition and binding of a formamidopyrimidine (FapyG) [Homo sapiens] [BlackBoxEvent:9656948] OGG1alpha translocates to the nucleus [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22 [InstanceEdit:9663702] Vlahopoulos, Spiros, 2019-10-02 [InstanceEdit:9663703] Boldogh, Istvan, 2019-10-08
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360522] R-HSA-110244.3
summation	[Summation:178547] OGG1 acts as an N-glycosylase and a DNA beta-lyase to excise...
(hasEvent)	[Pathway:110329] Cleavage of the damaged pyrimidine [Homo sapiens]
(normalReaction)	[FailedReaction:9656252] Defective OGG1 mutants do not excise FapyG [Homo sapiens]
(precedingEvent)	[Reaction:110354] Displacement of OGG1 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:5649701] NEIL1,NEIL2 displace OGG1 from AP-dsDNA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777442] Update Tracker - [Reaction:110244] Excision of FapyG by OGG1 glycosylase - v71:[modifyText] [_UpdateTracker:9785346] Update Tracker - [Reaction:110244] Excision of FapyG by OGG1 glycosylase - v52:[add_removeCatalystActivity, modifyText, removeLiteratureReference] [_UpdateTracker:9785827] Update Tracker - [Reaction:110244] Excision of FapyG by OGG1 glycosylase - v51:[addLiteratureReference, add_removeOutput, modifyText]
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